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Targeting Lysine Demethylases in Cancer and Other Human Diseases

  • Book
  • © 2023

Overview

Editors:
  1. Qin Yan

    1. Department of Pathology, Yale School of Medicine, New Haven, USA

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  • Reviews our knowledge on lysine demethylases
  • Provides insights into the therapeutic strategies targeting demethylases
  • Offers a perspective for future discoveries in biology

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1433)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-vii
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  2. Lysine Demethylation in Pathogenesis

    • Jian Cao, Qin Yan
    Pages 1-14

  3. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases

    • Fei Mao, Yujiang Geno Shi
    Pages 15-49

  4. Biological Functions of the KDM2 Family of Histone Demethylases

    • Jaclyn Andricovich, Alexandros Tzatsos
    Pages 51-68

  5. Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression

    • Lingling Fan, Khadka Sudeep, Jianfei Qi
    Pages 69-86

  6. KDM4 Demethylases: Structure, Function, and Inhibitors

    • Yuanyuan Jiang, Lanxin Liu, Zeng-Quan Yang
    Pages 87-111

  7. KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic

    • Shang-Min Zhang, Jian Cao, Qin Yan
    Pages 113-137

  8. Context-Dependent Functions of KDM6 Lysine Demethylases in Physiology and Disease

    • Mina Masoumeh Tayari, Celestia Fang, Panagiotis Ntziachristos
    Pages 139-165

  9. KDM7 Demethylases: Regulation, Function and Therapeutic Targeting

    • Peng Shao, Qi Liu, Hank Heng Qi
    Pages 167-184
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Keywords

About this book

This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications.


The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.

Editors and Affiliations

  • Department of Pathology, Yale School of Medicine, New Haven, USA

    Qin Yan

Bibliographic Information

  • Book Title: Targeting Lysine Demethylases in Cancer and Other Human Diseases

  • Editors: Qin Yan

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-031-38176-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-38175-1Published: 27 September 2023

  • Softcover ISBN: 978-3-031-38178-2Due: 15 April 2024

  • eBook ISBN: 978-3-031-38176-8Published: 26 September 2023

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VII, 184

  • Number of Illustrations: 7 b/w illustrations, 28 illustrations in colour

  • Topics: Cancer Research

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