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Heterocycles from Carbenes and Nitrenes

Methods, Reactions and Synthetic Applications

  • Book
  • © 2023

Overview

Editors:
  1. Michael P. Doyle

    1. Department of Chemistry, University of Texas at San Antonio, San Antonio, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Xinfang Xu

    1. Sun Yat-sen University, Guangzhou, China

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    You can also search for this editor in PubMed   Google Scholar

  • The uses of carbene and nitrene species in the generation of traditional and novel heterocyclic compounds.
  • Multiple methods to enter carbene and nitrene species for heterocyclic syntheses.
  • Carbene-generated products as precursors to heterocycles.

Part of the book series: Topics in Heterocyclic Chemistry (TOPICS, volume 59)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Photo-Induced Carbene Transformations to Heterocycles

    • Joseph P. Milton, Dorota Gryko
    Pages 1-33

  3. Heterocycles from Onium Ylides

    • Claire Empel, Rene M. Koenigs
    Pages 35-62

  4. Heterocycles from Sulfur Ylides

    • Antonio C. B. Burtoloso, Jorge A. M. Vargas, Matheus P. de Jesus, Radell Echemendía
    Pages 63-105

  5. Heterocycles from Cascade Reactions via Carbene gem-Difunctionalization

    • Mengchu Zhang, Xinfang Xu, Wenhao Hu
    Pages 107-156

  6. Heterocycles from Cyclopropanation of Five-Membered Heteroarenes

    • Kathrin Strunk, Oliver Reiser
    Pages 157-185

  7. Heterocycles from Cycloaddition Reactions

    • Kostiantyn O. Marichev
    Pages 187-223

  8. Alkynes as Carbene Precursors for the Synthesis of Heterocycles

    • Long-Wu Ye
    Pages 225-268

  9. Heterocycles from Donor and Donor/Donor Carbenes

    • Dong Zhu, Shifa Zhu
    Pages 269-312

  10. An Overview of N-Heterocycle Syntheses Involving Nitrene Transfer Reactions

    • Ken Lee, Kyeongdeok Seo, Mahzad Dehghany, Yun Hu, Anh Trinh, Jennifer M. Schomaker
    Pages 313-377
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Keywords

About this book

This book provides researchers in the fields of organic chemistry, organometallic chemistry and homogeneous catalysis with an overview of recent developments in the applications of reactions involving carbene and nitrene intermediates directed to the synthesis of heterocyclic compounds. Multiple pathways through which diverse heterocyclic compounds are accessed occur from a variety of carbene and nitrene precursors through C-H/X-H insertions, cycloadditions, ylide transformations, rearrangements, and cascade reactions. Catalytic processes that form metallo-carbenes and nitrenes offer unparalleled chemo-, regio-, and stereo-selectivities. Insights are provided into the scope of these methodologies and the inherent control of catalyst ligands on reaction selectivities.

Editors and Affiliations

  • Department of Chemistry, University of Texas at San Antonio, San Antonio, USA

    Michael P. Doyle

  • Sun Yat-sen University, Guangzhou, China

    Xinfang Xu

About the editors

Michael P. Doyle is the Rita and John Feik Distinguished University Chair in Medicinal Chemistry at the University of Texas at San Antonio. He is a graduate of the College of St. Thomas and Iowa State University, has had academic appointments at undergraduate institutions (Hope College and Trinity University) and graduate universities (University of Arizona and University of Maryland) before taking his current position. He is widely recognized for his research in catalytic methods for metal carbene transformations.

Xinfang Xu is graduated from East China Normal University (bachelor's degree in 2005, and Ph.D. in 2010), then conducted postdoctoral study at University of Maryland with Prof. Michael P. Doyle (2010-2014). In 2014, he started his independent career at Soochow University. He is now a full professor at Sun Yat-sen University, where his research interests include catalytic carbene gem-difunctionalization and cascade reaction, asymmetric catalysis, and bioactivity-oriented heterocycle syntheses.

Bibliographic Information

  • Book Title: Heterocycles from Carbenes and Nitrenes

  • Book Subtitle: Methods, Reactions and Synthetic Applications

  • Editors: Michael P. Doyle, Xinfang Xu

  • Series Title: Topics in Heterocyclic Chemistry

  • DOI: https://doi.org/10.1007/978-3-031-36735-9

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-36734-2Published: 10 August 2023

  • Softcover ISBN: 978-3-031-36737-3Due: 10 September 2023

  • eBook ISBN: 978-3-031-36735-9Published: 09 August 2023

  • Series ISSN: 1861-9282

  • Series E-ISSN: 1861-9290

  • Edition Number: 1

  • Number of Pages: VII, 377

  • Number of Illustrations: 346 b/w illustrations, 119 illustrations in colour

  • Topics: Chemistry/Food Science, general, Organic Chemistry, Energy Materials, Energy Materials

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