Overview
- Provides a complete picture of the latest findings in RNA structure and function
- Inspires researchers and students with applications of latest technologies in the field
- Describes the role of RNA in basic biological processes and disorders, such as cancer
Part of the book series: RNA Technologies (RNATECHN, volume 14)
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Table of contents (29 chapters)
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Front Matter
Keywords
- RNA structure
- RNA function
- transfer RNA
- non-coding RNA
- RNA nanoparticles
- RNA and protein interactome
- HyPro technology
- in silico elucidation of RNA structures
- RNA crytallography
- riboswitchers
- non-coding RNA in cancer
- RNA-RNA interaction
- fuctional analysis of circular RNA
- viroids
- RNA G-quadruplexes
- piRNA in cancer epigenetics
- DNAzymes and RNA
- genome-wide computational prediction of RNA structures
- nanopore technology
About this book
This book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.
RNA, in one form or another, touches almost everything in a cell. RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing environments. RNAs are involved in various aspects of cell physiology and disease development. Discoveries of RNA with unexpected diverse functions in healthy and diseased cells,such as the role of RNA as both the source and countermeasure to cancer or severe viral infection, stimulate new trends, passion, and solutions for molecular medicine.In this book, fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, how to determine RNA structure and how to apply RNA in treatment of diseases.
This book is an essential resource for researches in academia and industry contributing to the development of new RNA therapeutics. The book is geared toward scientists from the graduate level on up and particularly appeals to active investigators in RNA biology, molecular biology, and biochemistry.
Editors and Affiliations
About the editor
Jan Barciszewski is Professor at Adam Mickiewicz University (AMU) in Poznań, Poland, and at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland, where he has worked since 1974. He studied organic chemistry at the AMU. During his Ph.D. studies, he worked on the structure and function of modified bases and nucleoside sequences of plant phenylalanine-specific transfer ribonucleic acid (tRNA), including cytokinins. He was subsequently granted Doctor of Science degree for his work on the properties of plant tRNAs and aminoacyl-tRNA synthetases. In the 1990s, he began working on the diagnosis and therapy of brain tumors. He developed a new method for the transformation of plant mitochondria based on catalytic RNAs and is currently involved in studies on a new type of catalytic RNAs (enantiomeric ribozymes) for efficient RNA target cleavage in vivo, as well as the search for new anti-aging agents.
Bibliographic Information
Book Title: RNA Structure and Function
Editors: Jan Barciszewski
Series Title: RNA Technologies
DOI: https://doi.org/10.1007/978-3-031-36390-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-36389-4Published: 04 November 2023
Softcover ISBN: 978-3-031-36392-4Due: 05 December 2023
eBook ISBN: 978-3-031-36390-0Published: 03 November 2023
Series ISSN: 2197-9731
Series E-ISSN: 2197-9758
Edition Number: 1
Number of Pages: XI, 666
Number of Illustrations: 11 b/w illustrations, 123 illustrations in colour
Topics: Life Sciences, general, Biochemistry, general, Human Genetics, Cell Biology, Genetics and Genomics