Overview
- Outlines the development of glucocorticoid receptor modulators from 1950 to 2022
- Shows how prodrugs and metabolic inactivation are applied to drug discovery
- Presents Antibody-Drug Conjugates for immunology
Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)
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Table of contents (8 chapters)
Keywords
About this book
Authors and Affiliations
About the author
Adrian Hobson, FRSC, is a Senior Research Fellow at Abbvie, and an adjunct Professor of Chemistry at Clark University in Worcester, MA, USA. With 30 years of experience as a medicinal chemist, he started his journey at Boots Pharmaceuticals, Nottingham UK, where he worked on anti-depressants and anti-psychotics, and in the Special Synthesis group making metabolites and possible impurities. After the company was acquired by BASF in 1994, he formed the High Speed Analoging team, working there for 6 years until he transferred to the BASF Bioresearch Corporation at Worcester, MA, USA, where he formed a new High Speed Analoging team to support both oncology and immunology. He spent the next 12 years working in medicinal chemistry on kinase, GPCR and NHR targets including selective glucocorticoid receptor modulators. When AbbVie split from Abbott, Dr Hobson switched his attention to immunology antibody-drug conjugates, where he has pioneered the use of glucocorticoid receptor modulators (GRM) as a payload for antibody-drug conjugates.
Bibliographic Information
Book Title: The Medicinal Chemistry of Glucocorticoid Receptor Modulators
Authors: Adrian Hobson
Series Title: SpringerBriefs in Molecular Science
DOI: https://doi.org/10.1007/978-3-031-28732-9
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Softcover ISBN: 978-3-031-28731-2Published: 12 April 2023
eBook ISBN: 978-3-031-28732-9Published: 11 April 2023
Series ISSN: 2191-5407
Series E-ISSN: 2191-5415
Edition Number: 1
Number of Pages: IX, 142
Number of Illustrations: 172 b/w illustrations
Topics: Medicinal Chemistry, Pharmaceutical Sciences/Technology, Theoretical and Computational Chemistry, Computer Applications in Chemistry, History of Chemistry