Overview
- Sheds light on new aspects in centrosome functions
- Discusses centrosomes significant impact on cellular functions and dysfunctions
- Provides a valuable resource for newcomers and experts in the field
Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 235)
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Table of contents (10 chapters)
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Front Matter
Keywords
About this book
The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research.
Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders.
This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research.
Authors and Affiliations
About the author
Dr. Heide Schatten, University of Missouri, Columbia, is a cell and reproductive biologist with specific expertise in cytoskeletal and centrosome biology. She has published over 300 papers focused on cell and molecular biology of the cytoskeleton and cell organelles including mitochondria and interactions with other cell organelles and cellular structures. She has further published numerous book chapters and edited several special topics journal issues and she edited 18 books with several more books in progress.
Her publications include advanced imaging methods, cellular and molecular biology, cancer biology, reproductive biology, microbiology and space biology. The latter included collaborations with NASA scientists and experiments aboard the Space Shuttle Endeavour to examine the effects of spaceflight on cytoskeletal organization during development. She has received numerous awards including grant awards from NASA, NIH, and NSF.Bibliographic Information
Book Title: The Centrosome and its Functions and Dysfunctions
Authors: Heide Schatten
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-031-20848-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Softcover ISBN: 978-3-031-20847-8Published: 17 December 2022
eBook ISBN: 978-3-031-20848-5Published: 16 December 2022
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: VII, 111
Number of Illustrations: 1 b/w illustrations, 17 illustrations in colour
Topics: Cell Biology, Physiology, Biomedicine, general, Cancer Research, Developmental Biology