Overview
- Overview of hot topics in scanning ion conductance microscopy (SICM)
- Presents recent applications of SICM and advantages over other techniques
- Multi-authored volume with contributions from experts in the field
Part of the book series: Bioanalytical Reviews (BIOREV, volume 3)
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Table of contents (8 chapters)
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Front Matter
Keywords
About this book
This book provides a selection of recent developments in scanning ion conductance microscopy (SICM) technology and applications. In recent years, SICM has been applied in an ever-increasing number of areas in the bioanalytical sciences. SICM is based on an electrolyte-filled nanopipette with a nanometer-scale opening, over which an electric potential is applied. The induced ion current is measured, which allows to directly or indirectly quantify various physical quantities such as pipette-sample distance, ion concentration, sample elastic modulus among many others. This makes SICM well suited for applications in electrolytes - most prominently for the study of live cells.
This book starts with a historic overview starting from the days of the invention of SICM by Paul Hansma at the University of California at Santa Barbara in 1989. SICM is a member of the family of scanning probe microscopies. It is related to another prominent member of the family, atomic force microscopy (AFM), which has found application in almost any field of nanoscale science. The advantages and disadvantages of SICM over AFM are also outlined. One of the most effective and break-through applications of SICM nanopipettes is in electrochemistry. The different routes and applications for doing electrochemistry using nanopipettes are also discussed. In addition the book highlights the ability of SICM for surface positioning with nanometer precision to open up new vistas in patch clamp measurements subcellular structures. Finally the book presents one research area where SICM has been making a lot of contributions, cardiac research and the endeavors to combine SICM with super-resolution optical microscopy for highest-resolution joint topography and functional imaging.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Scanning Ion Conductance Microscopy
Editors: Tilman E. Schäffer
Series Title: Bioanalytical Reviews
DOI: https://doi.org/10.1007/978-3-031-14443-1
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-14442-4Published: 30 September 2022
Softcover ISBN: 978-3-031-14445-5Published: 02 October 2023
eBook ISBN: 978-3-031-14443-1Published: 28 September 2022
Series ISSN: 1867-2086
Series E-ISSN: 1867-2094
Edition Number: 1
Number of Pages: XI, 230
Topics: Analytical Chemistry, Materials Science, general, Biological and Medical Physics, Biophysics, Chemistry/Food Science, general, Biotechnology, Biomaterials