Cancer Stem Cell Markers and Related Network Pathways

1. Front Matter

   Pages i-xiv

   PDF

2. Epithelial–Mesenchymal Transition and Cancer Stem Cells

   • Shihori Tanabe

   Pages 1-49

3. The Transcription Factors Zeb1 and Snail Induce Cell Malignancy and Cancer Stem Cell Phenotype in Prostate Cells, Increasing Androgen Synthesis Capacity and Therapy Resistance

   • Fernanda López-Moncada, Enrique A. Castellón, Héctor R. Contreras

   Pages 51-64

4. ERBB Signaling Pathway in Cancer Stem Cells

   • Ghmkin Hassan, Masaharu Seno

   Pages 65-81

5. Functional and Molecular Characters of Cancer Stem Cells Through Development to Establishment

   • Said M. Afify, Ghmkin Hassan, Hiroko Ishii, Sadia Monzur, Hend M. Nawara, Amira Osman et al.

   Pages 83-101

6. Microenvironment of Cancer Stem Cells

   • Shihori Tanabe

   Pages 103-124

7. Cancer Stem Cells Contribute to Drug Resistance in Multiple Different Ways

   • Maram H. Zahra, Hend M. Nawara, Ghmkin Hassan, Said M. Afify, Akimasa Seno, Masaharu Seno

   Pages 125-139

8. Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target

   • Sabina Quader, Shihori Tanabe, Horacio Cabral

   Pages 141-156

This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype.


This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways.


The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters.   


The topic of this book is particularly relevant to research in thefield of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.

• Epithelial-mesenchymal transition
• Gene expression
• Cellular signaling
• Drug resistance
• Cancer therapy

• National Institute of Health Sciences, Kanagawa, Japan

  Shihori Tanabe

Shihori Tanabe, Ph.D. has been working as a Senior Researcher at the Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences from April 2016. From Apr 2005 until Jan 2006 she held a position of a Post Doctoral Fellow at the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo. From Feb 2006 until Mar 2010 she worked as a Researcher at the Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo Japan. She also had a position of a Senior Researcher at the Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences (Apr 2010 - Mar 2016, Tokyo Japan)

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