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Ancistrocladus Naphthylisoquinoline Alkaloids

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  • © 2023

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  • Written by recognized authorities in the field
  • Provides comprehensive and up-to-date reviews on the topic
  • Is a part of a well-known series

Part of the book series: Progress in the Chemistry of Organic Natural Products (POGRCHEM, volume 119)

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Table of contents (1 chapter)

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About this book

This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.

Editors and Affiliations

  • College of Pharmacy, Ohio State University, Columbus, USA

    A. Douglas Kinghorn

  • Institute of Organic Chemistry, Johannes Kepler University of Linz, Linz, Austria

    Heinz Falk

  • Centre for Natural Products Discovery, Liverpool John Moores University, Liverpool, UK

    Simon Gibbons

  • Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  • School of Pharmaceutical Sciences, South Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

  • Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria

    Verena M Dirsch

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