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Part of the book series: Progress in the Chemistry of Organic Natural Products (POGRCHEM, volume 119)
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Table of contents (1 chapter)
Keywords
About this book
This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
Editors and Affiliations
Bibliographic Information
Book Title: Ancistrocladus Naphthylisoquinoline Alkaloids
Editors: A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, Verena M Dirsch
Series Title: Progress in the Chemistry of Organic Natural Products
DOI: https://doi.org/10.1007/978-3-031-10457-2
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-10456-5Published: 02 January 2023
Softcover ISBN: 978-3-031-10459-6Published: 03 January 2024
eBook ISBN: 978-3-031-10457-2Published: 01 January 2023
Series ISSN: 2191-7043
Series E-ISSN: 2192-4309
Edition Number: 1
Number of Pages: XI, 335
Number of Illustrations: 140 b/w illustrations, 106 illustrations in colour
Topics: Organic Chemistry, Biochemistry, general, Chemistry/Food Science, general, Pharmaceutical Sciences/Technology