Biomarkers in Toxicology

This handbook of the series Biomarkers in Disease informs comprehensively about all aspects of monitoring and detecting toxicity in the human body and model organisms. Biomarkers for assessing toxicity in diverse organs are presented and different assays and methods are explained. Single compounds and drugs and their toxicity for humans are shown and the methods for detection described.

Similar to all the volumes of the Biomarkers in Disease series, the chapters are written by experts in their field, each chapter features key facts summarizing the most important aspects of its respective topic and the definitions of words and terms facilitate the reading and understanding.  

This handbook is a must-have for researchers in toxicology and biomedicine who analyze the effects of drugs and various other substances in the human body and in model organisms. It also serves as a thorough guide for clinicians and pharmacologists.

• biomarkers in toxicity studies
• skin toxicity
• nutritional toxicity
• Challenge-comet assay
• CRISPR/Cas9 whole genome screens
• Apoptotic biomarkers
• oxidative stress markers
• nanoparticle-induced toxicity
• iPSCs as biomarkers
• trastuzumab and toxicity
• anti-inflammatory biomarkers
• Urinary biomarkers
• blood brain barrier as biomarker
• alcohol toxicity
• Hair metabolomics
• drugs and toxicity
• heavy metals in blood
• hepatotoxicity
• DNA adducts

• School of Life Sciences, University of Westminster, London, UK

  Vinood B. Patel

• School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK

  Victor R. Preedy

• College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

  Rajkumar Rajendram

Vinood B. Patel, BSc, PhD, FRSC, is a Reader in Clinical Biochemistry at the University of Westminster.  Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. In 2014, he was elected as a Fellow to The Royal Society of Chemistry. Dr Patel is a nationally and internationally recognized researcher and was involved in several NIH-funded biomedical grants related to disease. Dr Patel has extensively published biomedical books in the area of diet, biomarkers, toxicology, nutrition and health prevention.

Victor R. Preedy PhD, DSc, FRSC, FRSB, FRSPH, FRCPath is Professor of Clinical Biochemistry andPathology in King’s College Hospital and Emeritus Professor of Nutritional Biochemistry in King’s College London. Professor Preedy graduated in 1974 with a Combined Honours Degree in Biology and Physiology with Pharmacology. He gained his Ph.D. in 1981, in the field of nutrition and metabolism, from the London School of Hygiene and Tropical Medicine, University of London. His second doctorate was awarded for his work on protein metabolism, with a focus on toxicity.   Professor Preedy is a Fellow to four Royal Colleges and has published over 700 articles, including abstracts, peer-reviewed works, reviews and books.

Rajkumar Rajendram, AKC, BSc (Hons), MBBS (Dist), EDIC, FRCP Lond is a Consultant at King Abdulaziz Medical City, and Joint Appointment Assistant Professor of Medicine at King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. In 2001, Dr Rajendram graduated with honours from King’s College, London. He thentrained in general medicine and intensive care in Oxford, attaining membership of the Royal College of Physicians (MRCP) in 2004, and becoming a Consultant at the John Radcliffe Hospital, Oxford, in 2011. Dr Rajendram also trained in anaesthesia and became a fellow of the Royal College of Anaesthetists (FRCA) in 2009, and a fellow of the Faculty of Intensive Care Medicine (FFICM) in 2014. During his medical training was also a visiting lecturer at King’s College London; devoting significant time and effort into research on toxicology and nutrition. He has published over 300 textbook chapters, review articles, peer-reviewed papers, and abstracts.

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