Overview
- Outlines new promising drug targets for Neglected Tropical Diseases
- Describes new strategies of antiprotozoal drug delivery
- Supports the UN Sustainable Development Goal on Good Health and Well-being
Part of the book series: Topics in Medicinal Chemistry (TMC, volume 39)
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Table of contents (15 chapters)
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Front Matter
Keywords
- Protozoan Infections
- Antiprotozoal Agents
- Neglected Tropical Diseases
- Drug Delivery Systems against Leishmaniasis
- Drug Development for Chagas Disease
- Antimalarials
- Trypanosoma cruzi
- Saponins
- Trypanosoma brucei infection
- Enatamoeba histolytica infection
- Trichominas vaginalis Treatment
- Toxoplasmosis Treatment
About this book
This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates.
The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.
Editors and Affiliations
About the editors
Alane Beatriz Vermelho is Full Professor at the Federal University of Rio de Janeiro (UFRJ), Brazil, where she coordinates the Laboratory of the Biotechnology Network BIONOVAR - Biocatalysis, Bioproducts and Bioenergy Unit. She received her Ph.D. in Microbiology in 1991 from the Institute of Microbiology Paulo de Góes – UFRJ, Brazil, and in 2006 she carried out postdoctoral research at EMBRAPA, a research corporation affiliated with the Brazilian Ministry of Agriculture. She acted as Director of the Microbiology Institute Paulo de Góes of UFRJ and member of the Executive Group of the Industrial Complex of the Life Sciences until 2016. She is currently a member of the Committee for Management and Evaluation of Intellectual Property of UFRJ and GT - Microbiology of the Brazilian Institute of Petroleum, Gas and Biofuels (IBP). She has been actively promoting the academia-industry interaction throughout her career, and is a member of the joint Management Committee UFRJ-Empresas / UFRJ of the technological park.
Claudiu T. Supuran is a Full Professor of Medicinal Chemistry at Dipartimento Neurofarba, Universita` degli Studi di Firenze, Sezione di Scienze Farmaceutiche e Nutraceutiche, Florence, Italy. He received his BSc in Chemistry from the Polytechnic University of Bucharest, Romania (1987), and Ph. D. in Chemistry at the same university in 1991. His research interests focus on drug development against Carbonic anhydrases and other enzymes. He has published 1700+ research articles on carbonic anhydrase enzyme research, being one of the most cited medicinal chemists worldwide. His research is also focused on enzyme inhibitors and activators, carbonic anhydrases, heterocyclic chemistry, chemistry of sulfonamides, sulfamates and sulfamides, X-ray crystallography of metallo-enzymes, biologically active organo-element derivatives, quantitative structure-activity relationship (QSAR) studies, metal-based drugs, cyclooxygenases inhibitors, serineproteases, matrix metalloproteinases, bacterial proteases, antivirals, antitumor drugs, ophthalmologic drugs and amino acid derivatives. One sulfonamide carbonic anhydrase inhibitor discovered in his laboratory, SLC-0111, completed Phase I clinical trials as antitumor/antimetastatic agent in 2014 and is presently in Phase Ib/II clinical trials in Canada, being developed for the treatment of advanced, metastatic solid tumors.
Bibliographic Information
Book Title: Antiprotozoal Drug Development and Delivery
Editors: Alane Beatriz Vermelho, Claudiu T. Supuran
Series Title: Topics in Medicinal Chemistry
DOI: https://doi.org/10.1007/978-3-031-06850-8
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-06849-2Published: 26 June 2022
Softcover ISBN: 978-3-031-06852-2Published: 27 June 2023
eBook ISBN: 978-3-031-06850-8Published: 24 June 2022
Series ISSN: 1862-2461
Series E-ISSN: 1862-247X
Edition Number: 1
Number of Pages: X, 331
Topics: Medicinal Chemistry, Biotechnology, Biological Techniques, Medical Microbiology, Parasitology, Health Promotion and Disease Prevention