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Understanding PTMs in Neurodegenerative Diseases

  • Book
  • © 2022

Overview

Editors:
  1. Victor Corasolla Carregari

    1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

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  • Increases awareness of how PTMs may help researchers understand mechanisms in neurodegenerative diseases
  • Explains how proteomic studies of PTMs can be applied to neurodegenerative diseases and relevant studies
  • Describes different PTMs enrichment methods, tools, and techniques to apply and better analyze their data

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1382)

Part of the book sub series: Proteomics, Metabolomics, Interactomics and Systems Biology (PMISB)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Protein Extraction and Sample Preparation Methods for Shotgun Proteomics with Central Nervous System Cells and Brain Tissue

    • Victor Corasolla Carregari
    Pages 1-15

  3. Phosphopeptide Enrichment Techniques: A Pivotal Step for Phosphoproteomic Studies

    • Victor Corasolla Carregari
    Pages 17-27

  4. Post-Translational Modifications During Brain Development

    • Bradley J. Smith, Victor Corasolla Carregari
    Pages 29-38

  5. Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma

    • Livia Rosa-Fernandes, Sueli Mieko Oba-Shinjo, Janaina Macedo-da-Silva, Suely Kazue Nagahashi Marie, Giuseppe Palmisano
    Pages 39-70

  6. Post-translational Modification in Muscular Dystrophies

    • Martina Sandonà, Valentina Saccone
    Pages 71-84

  7. Post-translational Modifications in Parkinson’s Disease

    • André Saraiva Leão Marcelo Antunes
    Pages 85-94

  8. Histone Modifications in Neurological Disorders

    • Bradley J. Smith, Victor Corasolla Carregari
    Pages 95-107

  9. Mitochondrial Dysregulation and the Influence in Neurodegenerative Diseases

    • Giuliana S. Zuccoli, Victor Corasolla Carregari
    Pages 109-118

  10. PTMs: A Missing Piece for Schizophrenia Studies

    • Caroline Brandão-Teles, Bradley J. Smith, Victor Corasolla Carregari
    Pages 119-127

  11. Post-translational Modifications in Brain Diseases: A Future for Biomarkers

    • Licia C. Silva-Costa, Bradley J. Smith
    Pages 129-141

  12. Back Matter

    Pages 143-146
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Keywords

About this book

This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. 

Editors and Affiliations

  • Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Victor Corasolla Carregari

About the editor

Dr . Victor Corasolla Carregari is a fellow researcher in the biochemistry department at the University of Campinas (UNICAMP) in Brazil with a focus on proteomics and metabolomics. His research interests include proteomics and PTMs, metabolomics, exosomes isolation and characterization, and functional validations of proteomics data. Dr. Corasolla Carregari received his Master and PhD in functional and molecular biology at UNICAMP.

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