From Obesity to Diabetes

1. Front Matter

   Pages i-viii

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2. Obesity

   1. Front Matter

      Pages 1-1

      PDF

   2. Epidemiology of Obesity

      • Thorkild I. A. Sørensen, Andrea Rodriguez Martinez, Terese Sara Høj Jørgensen

      Pages 3-27

   3. The Circadian Clock and Obesity

      • Yasmine Sebti, Aurore Hebras, Benoit Pourcet, Bart Staels, Hélène Duez

      Pages 29-56

   4. Nutrition and Microbiome

      • Nathalie M. Delzenne, Julie Rodriguez

      Pages 57-73

   5. From Obesity to Diabetes: The Role of the Adipose Organ

      • Georgia Colleluori, Jessica Perugini, Antonio Giordano, Saverio Cinti

      Pages 75-92

   6. Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy

      • Gianluca Iacobellis, Sara Basilico, Alexis Elias Malavazos

      Pages 93-108

   7. The Enteroendocrine System in Obesity

      • Emily L. Miedzybrodzka, Frank Reimann, Fiona M. Gribble

      Pages 109-129

   8. Insights from Studies of White Adipose Tissue Using Single-Cell Approaches

      • Niklas Mejhert, Mikael Rydén

      Pages 131-144

   9. Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction

      • Gabriele Mocciaro, Amalia Gastaldelli

      Pages 145-164

   10. Obesity, Senescence, and Senolytics

       • Selim Chaib, Tamara Tchkonia, James L. Kirkland

       Pages 165-180

   11. Obesity and Obstructive Sleep Apnea

       • Maria R. Bonsignore

       Pages 181-201

3. Diabetes and Complications

   1. Front Matter

      Pages 203-203

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   2. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance

      • Megan Piquet, M. Carmen Martínez, Tania Romacho

      Pages 205-226

   3. Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes

      • Joyceline Cuenco, Elise Dalmas

      Pages 227-251

   4. NAFLD and NASH: The Metabolically Diseased Liver

      • Angelo Armandi, Jörn M. Schattenberg

      Pages 253-267

   5. Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities

      • Ara Aboolian, Sofia Urner, Michael Roden, Jay Chandra Jha, Karin Jandeleit-Dahm

      Pages 269-307

   6. Diabetic Peripheral Neuropathy

      • Johan Røikjer, Niels Ejskjaer

      Pages 309-328

4. Lifestyle Modifications and Future Treatments

   1. Front Matter

      Pages 329-329

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   2. Weight Loss Strategies

      • Susan B. Roberts, Stephen Anton, Maria C. Dao

      Pages 331-348

Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.

• obesity
• type 2 diabetes
• nutrition and microbiome
• epicardial fat
• brown fat
• sleep apnea
• organ crosstalk
• NAFLD and NASH
• cardiovascular disease
• diabetic neuropathy
• lifestyle modifications
• weight loss strategies
• physical activity
• bariatric surgery
• drug treatment of obesity and diabetes
• precision medicine

• Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany

  Juergen Eckel

• NutriOmique Research group, Nutrition Department, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université/INSERM, Paris, France

  Karine Clément

Policies and ethics