Editors:
- Shows a clear connection between ion transport and the initiation or progression of cancer
- Highlights dysregulated expression and activity of ion channels at all stages of a tumor disease
- Offers insights into the mediating role of ion transport, inbetween tumor cells and their environment
Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology (REVIEWS, volume 182)
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Table of contents (5 chapters)
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Front Matter
About this book
This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases.
Within the story of the various chapters, the authors line out various malfunctions of the transportome and where they can be found at different stages of the metastatic cascade. The authors describe how the interactions between the tumor cells' transportome and the environment reinforce mesenchymal behaviour of cancer cells and contribute to their uncontrolled proliferation, migration, invasion, intra- and extravasation up to the formation of metastases. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.
Editors and Affiliations
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Medizinische Hochschule Hannover, Zentrum für Innere Medizin, Hannover, Germany
Christian Stock
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Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
Luis A. Pardo
Bibliographic Information
Book Title: From Malignant Transformation to Metastasis
Book Subtitle: Ion Transport in Tumor Biology
Editors: Christian Stock, Luis A. Pardo
Series Title: Reviews of Physiology, Biochemistry and Pharmacology
DOI: https://doi.org/10.1007/978-3-030-99800-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-99799-1Published: 25 April 2022
Softcover ISBN: 978-3-030-99802-8Published: 25 April 2023
eBook ISBN: 978-3-030-99800-4Published: 24 April 2022
Series ISSN: 0303-4240
Series E-ISSN: 1617-5786
Edition Number: 1
Number of Pages: XV, 175
Number of Illustrations: 20 b/w illustrations, 20 illustrations in colour
Topics: Cancer Research, Medical Biochemistry, Pharmacology/Toxicology, Human Physiology, Cell Physiology