Overview
- Practical, user-friendly compendium of the critical tracer techniques used in basic and preclinical research
- Useful for both in vitro and in vivo models
- Methods include radioactive and non-radioactive isotopic tracers employed in basic and applied research
- Includes detailed examples, step-by-step instructions, and study questions
Part of the book series: Techniques in Life Science and Biomedicine for the Non-Expert (TLSBNE)
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Table of contents (3 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book serves as a practical guide and a manual on the application of isotopic tracers in understanding the cellular processes (e.g. molecular interactions, protein synthesis) in growth, development, and disease conditions. The techniques described in the book have been carefully chosen to underscore the role and relevance of isotopic tracers in the identification of molecular targets and mechanisms, and preclinical validation of potential therapeutics. This book is intended to be a valuable resource to non-experts that may include students, researchers, educators/teachers, and others who have an interest to understand the application of isotopic tracers in research. Each chapter includes a background, an outline of the method and underlying principles, and a detailed step-wise protocol. To augment the clarity and intellectual grasp, the chapters also include relevant illustrations and study questions. More importantly, the book covers techniques involving radioactive as well asnon-radioactive tracers to expand the scope of isotopes in preclinical research including basic and applied science.
Authors and Affiliations
About the author
Shanmugasundaram Ganapathy-Kanniappan holds a Ph.D. degree from the University of Madras, India. In 2006, he joined the Department of Radiology, Johns Hopkins University School of Medicine, as a junior faculty member and was quickly promoted to assistant professor. Before joining the Johns Hopkins, he underwent postdoctoral training in premier institutes such as the National Institute of Immunology (NII, New Delhi, India) and the University of California at Los Angeles (UCLA). His current research interests include metabolic alteration in human pathophysiology and the identification of molecular targets for therapeutic intervention. He has published over 50 articles including original reports, invited reviews, editorials, book chapters, and books (https://www.ncbi.nlm.nih.gov/myncbi/1xKsymd-il85x/bibliography/public/). He is an inventor and coinventor of several patents and a recipient of prestigious fellowships and research awards including funding from private and federal sponsors. He is on the editorial board of peer-reviewed journals and currently serves the journal, Frontiers in Oncology as an associate editor for the section, Cancer Molecular Targets and Therapeutics.
Bibliographic Information
Book Title: Isotopic Tracer Techniques in Preclinical Research
Authors: Shanmugasundaram Ganapathy-Kanniappan
Series Title: Techniques in Life Science and Biomedicine for the Non-Expert
DOI: https://doi.org/10.1007/978-3-030-99700-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-99699-4Published: 04 May 2022
Softcover ISBN: 978-3-030-99702-1Published: 05 May 2023
eBook ISBN: 978-3-030-99700-7Published: 03 May 2022
Series ISSN: 2367-1114
Series E-ISSN: 2367-1122
Edition Number: 1
Number of Pages: XIII, 66
Number of Illustrations: 11 b/w illustrations, 8 illustrations in colour
Topics: Molecular Medicine, Imaging / Radiology, Biomedical Engineering/Biotechnology, Pharmacotherapy