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Cardio-Oncology

Management of Toxicities in the Era of Immunotherapy

  • Book
  • © 2022

Overview

Editors:
  1. Antonio Russo

    1. Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy

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  2. Nicola Maurea

    1. Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy

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  3. Dimitrios Farmakis

    1. University of Cyprus Medical School, Nicosia, Cyprus

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  4. Antonio Giordano

    1. Sbarro Institute for Cancer Research & Molecular Medicine, Temple University, Philadelphia, USA

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  • Provides a complete and updated state-of-art review
  • Written by experts in the field
  • Addresses the future perspectives in the cardio-immunology field

Part of the book series: Current Clinical Pathology (CCPATH)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Background: Immunology and Cancer

    • Lorena Incorvaia, Valerio Gristina, Chiara Brando, Maria La Mantia, Antonio Russo
    Pages 1-4

  3. Available Immunotherapy Drugs in Oncology

    • Valerio Gristina, Federica Iacono, Chiara Lisanti, Maria La Mantia, Antonio Galvano
    Pages 5-23

  4. Immunotherapy Adverse Events

    • Alessandro Inno, Stefania Gori
    Pages 25-30

  5. Pathophysiology of Cardiac Toxicity

    • Dimitrios Farmakis
    Pages 31-43

  6. Cardiac Risk Factors for Immunotherapy

    • Andreina Carbone, Vincenzo Quagliariello, Martina Iovine, Maria Laura Canale, Nicola Maurea
    Pages 45-50

  7. Diagnostic Methods of Cardiac Immunotherapy Damaging

    • Girolamo Manno, Daniela Di Lisi, Giuseppina Novo
    Pages 51-61

  8. Biomarkers of Early Cardiotoxicity

    • Ettore Capoluongo
    Pages 63-71

  9. Management of Patients with Cardiac Toxicity: The Point of View of the Cardiologist

    • Andreina Carbone, Alessandro Inno, Fabian Islas, Nicola Maurea
    Pages 73-89

  10. Management of Patients with Cardiac Toxicity: The Point of View of the Oncologist

    • Paola Zagami, Stefania Morganti, Paolo Tarantino, Giuseppe Curigliano
    Pages 91-111

  11. Future Perspectives

    • Dimitrios Farmakis
    Pages 113-118

  12. Back Matter

    Pages 119-122
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Keywords

About this book

The development of immunotherapy in oncology field has revolutionized the prognosis of many types of cancer. The immune checkpoint inhibitors target receptors whose inhibition increases the activity of immune system cells against tumor cells. In recent years, new immunotherapies have been studied and approved in a growing number of tumors including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). This volume provides a complete and updated state-of-art review regarding the management of cardiovascular toxicities from new immunotherapies. The manuscript is divided into different sections starting from the relationship between cancer and immune system to let the reader understand the new molecular concepts under immunotherapy development. Subsequent chapters describe specifically the immunotherapy options in solid tumor treatment and the main features of the immuno-related cardiovascular complications. This volume is written by experts in the oncological and cardiovascular fields and aims to provide to clinicians who approach current cancer patients a useful tool to move through the paths of modern cardio-oncology. An important section would afford the most relevant interventions needed to manage the cardiac events, suggesting how to reduce their impact and effects on oncological outcomes. The text concludes by addressing future perspectives in the cardio-immunology field, discussing many aspects such as the early detection of cardiovascular damage and the potential role of liquid biopsy in new damage-related biomarkers discovery.



Editors and Affiliations

  • Department of Surgical, Oncological, and Oral Sciences, University of Palermo, Palermo, Italy

    Antonio Russo

  • Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy

    Nicola Maurea

  • University of Cyprus Medical School, Nicosia, Cyprus

    Dimitrios Farmakis

  • Sbarro Institute for Cancer Research & Molecular Medicine, Temple University, Philadelphia, USA

    Antonio Giordano

About the editors

Antonio Russo, MD

Department of Oncology - A.O.U.P. "P. Giaccone" University Hospital. 

Via del Vespro 129, CAP 90127 Palermo, Italy. 

Email: antonio.russo@usa.net

 

Nicola Maurea, MD

Division of Cardiology, Istituto Nazionale Tumori⁻IRCCS-Fondazione G.Pascale

Via Mariano Semmola, 52 80131  Napoli, Italy. 

Email: nicolamaurea@virgilio.it

 

Dimitrios Farmakis, MD, PhD, FESC, FHFA

Assoc. Professor, University of Cyprus Medical School

Shacolas Educational Centre for Clinical Medicine, 215 Palaios dromos Lefkosias Lemesou, 2029, Nicosia, Cyprus

Visiting Professor, National and Kapodistrian University of Athens Medical School

Athens University Hospital Attikon, 1 Rimini St, 12462, Athens, Greece

Email: farmakis.dimitrios@ucy.ac.cy; dimitrios_farmakis@yahoo.com

 

Antonio Giordano, MD

Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology

College of Science and Technology, Temple University

200 Tuttleman Learning Center 1809 N 13th Street 

Philadelphia, 19122 USA. 

Email:  giordano@temple.edu

Bibliographic Information

  • Book Title: Cardio-Oncology

  • Book Subtitle: Management of Toxicities in the Era of Immunotherapy

  • Editors: Antonio Russo, Nicola Maurea, Dimitrios Farmakis, Antonio Giordano

  • Series Title: Current Clinical Pathology

  • DOI: https://doi.org/10.1007/978-3-030-97744-3

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-97743-6Published: 10 August 2022

  • Softcover ISBN: 978-3-030-97746-7Published: 10 August 2023

  • eBook ISBN: 978-3-030-97744-3Published: 09 August 2022

  • Series ISSN: 2197-781X

  • Series E-ISSN: 2197-7828

  • Edition Number: 1

  • Number of Pages: XIV, 122

  • Number of Illustrations: 3 b/w illustrations, 18 illustrations in colour

  • Topics: Oncology, Cardiology, Pathology, Internal Medicine

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