Overview
- Sheds light on the importance of macropinocytosis in health and disease
- Provides an overview of the molecular mechanisms underlying macropinocytosis
- Covers the functional aspects of macropinocytosis from its evolutionary origins to complex mammalian systems
Part of the book series: Subcellular Biochemistry (SCBI, volume 98)
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Table of contents (11 chapters)
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Front Matter
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Functions of Macropinocytosis
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Front Matter
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Signaling Mechanisms Driving Macropinocytosis
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Front Matter
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Back Matter
Keywords
About this book
This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process.
Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
Editors and Affiliations
About the editor
Dr. Cosimo Commisso earned his Ph.D. in 2008 at the University of Toronto in the Department of Molecular Genetics and completed his Postdoctoral Fellowship in Cancer Biology at New York University Langone Medical Center in 2014. He is currently an Associate Professor and Program Director in the Sanford Burnham Prebys Medical Discovery Institute NCI-Designated Cancer Center in La Jolla, California. Dr. Commisso made a seminal contribution to the field of cancer research by identifying the way that pancreatic tumors augment their nutrient supply through boosting a process called macropinocytosis. This “cellular drinking” pathway allows tumors to obtain nutrients from their environment and supports tumor growth. Research in Dr. Commisso’s lab is centered on identifying novel drug targets in the macropinocytosis pathway that could be harnessed to develop new therapeutic modalities for cancer.
Bibliographic Information
Book Title: Macropinocytosis
Book Subtitle: Functions and Mechanisms
Editors: Cosimo Commisso
Series Title: Subcellular Biochemistry
DOI: https://doi.org/10.1007/978-3-030-94004-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-94003-4Published: 06 April 2022
Softcover ISBN: 978-3-030-94006-5Published: 07 April 2023
eBook ISBN: 978-3-030-94004-1Published: 05 April 2022
Series ISSN: 0306-0225
Series E-ISSN: 2542-8810
Edition Number: 1
Number of Pages: XI, 224
Number of Illustrations: 28 illustrations in colour
Topics: Cell Biology, Biomechanics, Membrane Biology, Biomedicine, general