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Transportome Malfunction in the Cancer Spectrum

Ion Transport in Tumor Biology

  • Book
  • © 2021

Overview

Editors:
  1. Christian Stock

    1. Medizinische Hochschule Hannover, Zentrum für Innere Medizin, Hannover, Germany

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  2. Luis A. Pardo

    1. Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Highlights the correlation between tumor malignancy and ion channel function and expression
  • Provides examples of how malfunctioning ion transport proteins promote cancer initiation and progression
  • Enriches the understanding of designing therapeutic approaches directed at the transportome

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology (REVIEWS, volume 181)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
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  2. Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression

    • Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, Ahmed Ahidouch
    Pages 1-38

  3. Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening

    • Valerio Farfariello, Natalia Prevarskaya, Dimitra Gkika
    Pages 39-56

  4. Ion Channels in Lung Cancer

    • Etmar Bulk, Luca Matteo Todesca, Albrecht Schwab
    Pages 57-79

  5. Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer

    • Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, Bayram Edemir
    Pages 81-104

  6. Transportome Malfunctions and the Hallmarks of Pancreatic Cancer

    • Qi Ling, Holger Kalthoff
    Pages 105-127

  7. How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer

    • Christian Stock
    Pages 129-222

  8. Ion Channels in Glioma Malignancy

    • Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, Fabio Franciolini
    Pages 223-267

  9. Membrane Transporters and Channels in Melanoma

    • Ines Böhme, Roland Schönherr, Jürgen Eberle, Anja Katrin Bosserhoff
    Pages 269-374

  10. Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application

    • Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, Juana M. García-Pedrero
    Pages 375-427
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Keywords

About this book

This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis. The authors highlight the role of the so-called transportome, which is defined by the entirety of ion transporters and ion channels. Thereby, readers will get a better understanding of the impact dysregulated ion transport has on the whole spectrum of cancer types. Cancers display deficiencies in several, sometimes interdependent members of the transportome.


Clinicians will be interested in the fact that controlled expression of ion transport proteins dramatically impacts the life span of cancer patients, as shown in recent studies. These observations offer a promising outlook for biomedical scientists, as members of the transportome could be the tumor markers of tomorrow - both for diagnostic and therapeutic purposes.


As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field. 

Editors and Affiliations

  • Medizinische Hochschule Hannover, Zentrum für Innere Medizin, Hannover, Germany

    Christian Stock

  • Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

    Luis A. Pardo

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