Overview
- Provides a unique perspective on practical aspects of ferroptosis, with in-depth coverage of pathologies from Cancer to COVID-19
- Gives a comprehensive and up-to-date guide of small molecules modulating ferroptosis and their potential mechanism of action
- Discusses other non-apoptotic forms of cell death and the role of ferritinophagy in ferroptosis
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1301)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis.
While covering basic concepts, the book delvesinto mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
Editors and Affiliations
About the editors
Dr. Andrés F. Flórez is currently a Postdoctoral Fellow in the Department of Molecular and Cellular Biology (MCB) at Harvard University. His research is focused in understanding the oncogene-based mechanisms regulating ferroptosis and to use this knowledge for designing new therapeutic strategies. He is also interested in the role of ferroptosis in controlling bacterial cell populations.
Dr. Hamed Alborzinia is a Postdoctoral Fellow in the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ). He also belongs to the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. His main research focus is to understand the metabolic properties of cancer cells in connection to novel forms of cell death, including ferroptosis.
Bibliographic Information
Book Title: Ferroptosis: Mechanism and Diseases
Editors: Andrés F. Florez, Hamed Alborzinia
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-62026-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-62025-7Published: 10 August 2021
Softcover ISBN: 978-3-030-62028-8Published: 11 August 2022
eBook ISBN: 978-3-030-62026-4Published: 09 August 2021
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: IX, 140
Number of Illustrations: 4 b/w illustrations, 33 illustrations in colour
Topics: Cancer Research, Human Genetics, Apoptosis, Oxidative Stress, Lipidology