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  • © 2019

Heat Shock Proteins in Neuroscience

  • Provides the most comprehensive review of contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases
  • Contains chapters contributed by specialists from key basic and clinical research laboratories at major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world
  • An important source of reference for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery

Part of the book series: Heat Shock Proteins (HESP, volume 20)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-ix
  2. Neurological Aspects of HSP

    1. Front Matter

      Pages 1-1
    2. Hsp60 Friend and Foe of the Nervous System

      • Antonella Marino Gammazza, Celeste Caruso Bavisotto, Francesca Rappa, Federica Scalia, Everly Conway de Macario, Alberto J. L. Macario et al.
      Pages 3-21
    3. Role of Heat Shock Proteins in Brain Tumors

      • George A. Alexiou
      Pages 23-28
    4. Role of HSP70 in Plasticity and Memory

      • Rossana Rosa Porto, Lucas de Oliveira Alvares
      Pages 53-67
    5. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke

      • Jong Youl Kim, Meiying Huang, Jong Eun Lee, Midori A. Yenari
      Pages 69-82
  3. Aspects of HSP in Neurodegenerative Diseases and Disorders

    1. Front Matter

      Pages 83-83
  4. Aspects of HSP in Multiple Sclerosis

    1. Front Matter

      Pages 147-147
    2. Role of Hsp70 in Multiple Sclerosis: An Overview

      • Maria Magdalena Barreca, Fabiana Geraci
      Pages 149-167
    3. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis

      • Benjamin E. Clarke, Bernadett Kalmar, Linda Greensmith
      Pages 169-185
  5. Development of HSP-Based Therapies for Neurological Disorders

    1. Front Matter

      Pages 187-187
    2. Therapeutic Drugs and Natural Products: The Effect of Suppressing Heat Shock Proteins (Hsp) in Brain Tumors

      • Elif MertoÄŸlu, Aslıhan Åžengelen, Ezgi Kıyga, Evren Önay-Uçar
      Pages 189-208
    3. Can Hsp Targeted Gene Therapy Be a New Hope for Gliomas?

      • Evren Önay-Uçar, Aslıhan Åžengelen, Elçin Güngör, Elif MertoÄŸlu, Murat Pekmez, Nazlı Arda
      Pages 209-230
    4. Engineering Chaperones for Alzheimer’s Disease: Insights from Drosophila Models

      • Alfonso Martín-Peña, Diego E. Rincon-Limas
      Pages 259-272

About this book

The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders.  

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Editors and Affiliations

  • Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, USA

    Alexzander A. A. Asea

  • Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, USA

    Punit Kaur

About the editors

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.


Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

Bibliographic Information

  • Book Title: Heat Shock Proteins in Neuroscience

  • Editors: Alexzander A. A. Asea, Punit Kaur

  • Series Title: Heat Shock Proteins

  • DOI: https://doi.org/10.1007/978-3-030-24285-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-24284-8Published: 11 November 2019

  • Softcover ISBN: 978-3-030-24287-9Published: 11 November 2020

  • eBook ISBN: 978-3-030-24285-5Published: 30 October 2019

  • Series ISSN: 1877-1246

  • Series E-ISSN: 1877-1254

  • Edition Number: 1

  • Number of Pages: IX, 307

  • Number of Illustrations: 26 b/w illustrations, 20 illustrations in colour

  • Topics: Protein Science

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access