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Multi-scale Extracellular Matrix Mechanics and Mechanobiology

Editors:

  • Broadens readers’ understanding of the importance of structure–function perspectives on soft biological tissue
  • Enhances our understanding of integrated, multi-scale experimental and modeling approaches in biological science
  • Reviews the key recent research on ECM mechanics and mechanobiology using state-of-the-art technologies in computational modeling, advanced optical imaging, and biomechanical characterization
  • Maximizes readers’ insights into the hierarchical, multi-scale nature of ECM in governing cell and tissue behaviors

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials (SMTEB, volume 23)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii
  2. Biomechanics and Mechanobiology of Extracellular Matrix Remodeling

    • Jay D. Humphrey, Marcos Latorre
    Pages 1-20
  3. Multi-scale Modeling of the Heart Valve Interstitial Cell

    • Alex Khang, Daniel P. Howsmon, Emma Lejeune, Michael S. Sacks
    Pages 21-53
  4. Cellular and Extracellular Homeostasis in Fluctuating Mechanical Environments

    • Béla Suki, Harikrishnan Parameswaran, Calebe Alves, Ascânio D. Araújo, Erzsébet Bartolák-Suki
    Pages 83-121
  5. Intrinsic Optical Imaging of ECM Mechanics

    • Raphaël Turcotte, Yanhang Zhang
    Pages 165-202
  6. Collagen Self-assembly: Biophysics and Biosignaling for Advanced Tissue Generation

    • David O. Sohutskay, Theodore J. Puls, Sherry L. Voytik-Harbin
    Pages 203-245
  7. Roles of Interactions Between Cells and Extracellular Matrices for Cell Migration and Matrix Remodeling

    • Jing Li, Wonyeong Jung, Sungmin Nam, Ovijit Chaudhuri, Taeyoon Kim
    Pages 247-282
  8. Quantification of Cell-Matrix Interaction in 3D Using Optical Tweezers

    • Satish Kumar Gupta, Jiawei Sun, Yu Long Han, Chenglin Lyu, Tianlei He, Ming Guo
    Pages 283-310
  9. Cell-Matrix Interactions in Cardiac Development and Disease

    • Matthew C. Watson, Erica M. Cherry-Kemmerling, Lauren D. Black III
    Pages 311-342
  10. Multi-scale Mechanics of Collagen Networks: Biomechanical Basis of Matrix Remodeling in Cancer

    • J. Ferruzzi, Y. Zhang, D. Roblyer, M. H. Zaman
    Pages 343-387
  11. Back Matter

    Pages 389-392

About this book

This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms. 

Editors and Affiliations

  • Department of Mechanical Engineering, Department of Biomedical Engineering and Division of Materials Science & Engineering, Boston University, Boston, USA

    Yanhang Zhang

About the editor

Dr. Yanhang (Katherine) Zhang is a Professor at Boston University’s Departments of Mechanical and Biomedical Engineering, and Division of Materials Science and Engineering. She received her double major B.S. degrees in Engineering Mechanics and Economics and Management from Tsinghua University, China, in 1998; and her M.S. and Ph.D. degrees in Mechanical Engineering from the University of Colorado at Boulder, in 2000 and 2003 respectively, and was also a postdoc there for two years. In 2006, Dr. Zhang became an Assistant Professor at Boston University, where she established the Multi-Scale Tissue Biomechanics Laboratory. Her research focuses on vascular biomechanics and the multi-scale mechanics and mechanobiology of the extracellular matrix. Her research has been funded the by National Institute of Health (NIH), National Science Foundation (NSF), and the Defense Advanced Research Projects Agency (DARPA). Dr. Zhang was awarded the Clare Boothe Luce Assistant Professorship from 2006–2011, and received the Young Faculty Award from DARPA in 2007, and Faculty Early Career Development (CAREER) Award from the NSF in 2010. Dr. Zhang was elected a Fellow of the American Society of Mechanical Engineers (ASME) in 2018.

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access