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Animal Models of Acute Neurological Injury

  • Book
  • © 2019

Overview

Editors:
  1. Jun Chen

    1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

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  2. Zao C. Xu

    1. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA

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  3. Xiao Ming Xu

    1. Indiana University School of Medicine, SNRI SCBIRG, Indianapolis, USA

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  4. John H. Zhang

    1. Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, USA

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  • Provides updated detailed information on models from the 1st edition
  • Includes chapters on additional models that were not in the 1st edition
  • Features full-color photographs of key surgical steps

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-x
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  2. Animal Care and Surgery

    1. Front Matter

      Pages 1-1
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    2. Animal Protocol

      • Laurel D. Schantz
      Pages 3-12

    3. Anesthesia and Analgesia for Research Animals

      • Lisa J. Brossia-Root, Tara M. Cotroneo, Gerry Hish
      Pages 13-34

    4. Rodent Surgical Procedures and Tissue Collection

      • Cesar Reis, Onat Akyol, Jay Malaguit, Lei Huang, Budbazar Enkhjargal, Richard Applegate II et al.
      Pages 35-54

    5. Brain Monitoring

      • Cesar Reis, Onat Akyol, Wing Man Ho, Richard Applegate II, Gary Stier, Robert Martin et al.
      Pages 55-69

    6. Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An Update

      • Christine D. Yarberry, Aaron H. Puckett, Stephen M. Onifer
      Pages 71-90

  3. Cerebral Ischemic Animal Models

    1. Front Matter

      Pages 91-91
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    2. Four-Vessel Occlusion Model in Rats

      • Ping Deng, Zao C. Xu
      Pages 93-105

    3. Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia

      • Ami P. Raval, Chunli Liu, Bingren R. Hu
      Pages 107-117

    4. Rodent Model of Pediatric Asphyxial Cardiac Arrest

      • Mioara D. Manole, Henry L. Alexander, Robert W. Hickey, Robert S. B. Clark
      Pages 119-130

    5. Transient Middle Cerebral Artery Occlusion Model in Rodents

      • Ying Mao, Wei Zhu, Guo-Yuan Yang
      Pages 131-143

    6. Targeted Occlusion to Surface and Deep Vessels in Neocortex Via Linear and Nonlinear Optical Absorption

      • David Kleinfeld, Beth Friedman, Patrick D. Lyden, Andy Y. Shih
      Pages 145-162

    7. Intraluminal Middle Cerebral Artery Occlusion Model in Mice

      • Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi, Hiroyuki Kinouchi
      Pages 163-172

    8. Inducing Hemorrhagic Transformation Following Middle Cerebral Artery Occlusion via Acute Hyperglycemia in Rats

      • Devin W. McBride, Derek Nowrangi, Wing Mann Ho, Jiping Tang, John H. Zhang
      Pages 173-187

    9. Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits

      • Zhongjie Shi, Kehuan Luo, Sidhartha Tan
      Pages 189-205

    10. A Model of Neonatal Focal Cerebral Ischemia-Reperfusion

      • Zinaida S. Vexler, Donna M. Ferriero
      Pages 207-215

  4. Cerebral Hemorrhage Animal Models

    1. Front Matter

      Pages 217-217
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    2. Monofilament Perforation Subarachnoid Hemorrhage Rat Model

      • Wing Mann Ho, Cesar Reis, Onat Akyol, Julian Cahill, Devin McBride, John H. Zhang
      Pages 219-230

    3. Filament Perforation Subarachnoid Hemorrhage Mouse Model

      • Hideyuki Kamii, Teiji Tominaga
      Pages 231-240
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Keywords

About this book

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation.

As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

Editors and Affiliations

  • Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

    Jun Chen

  • Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA

    Zao C. Xu

  • Indiana University School of Medicine, SNRI SCBIRG, Indianapolis, USA

    Xiao Ming Xu

  • Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Animal Models of Acute Neurological Injury

  • Editors: Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-3-030-16082-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-16080-7Published: 01 August 2019

  • eBook ISBN: 978-3-030-16082-1Published: 23 July 2019

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 2

  • Number of Pages: X, 544

  • Number of Illustrations: 176 b/w illustrations

  • Topics: Neurosciences, Neurology

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