Overview
- Editors:
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Massimo Sabatini
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Division de Rhumatologie, Institut de Recherches Servier, Suresnes, France
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Philippe Pastoureau
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Division de Rhumatologie, Institut de Recherches Servier, Suresnes, France
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Frédéric Ceuninck
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Division de Rhumatologie, Institut de Recherches Servier, Suresnes, France
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Table of contents (22 protocols)
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- Sylvie Thirion, Francis Berenbaum
Pages 1-14
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- Frédéric De Ceuninck, Christophe Lesur, Philippe Pastoureau, Audrey Caliez, Massimo Sabatini
Pages 15-22
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- Luis A. Solchaga, Jean F. Welter, Donald P. Lennon, Arnold I. Caplan
Pages 53-67
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- Audrey McAlinden, Jochen Haag, Brigitte Bau, Pia M. Gebhard, Thomas Aigner
Pages 79-100
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- Frédéric Mallein-Gerin, Jérôme Gouttenoire
Pages 101-104
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- Frédéric Mallein-Gerin, Jérôme Gouttenoire
Pages 105-108
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- Thomas Aigner, Joachim Saas, Alexander Zien, Ralf Zimmer, Pia M. Gebhard, Thomas Knorr
Pages 109-127
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- Jean F. Welter, Luis A. Solchaga, Matthew C. Stewart
Pages 129-145
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- Jean-Noel Gouze, Martin J. Stoddart, Elvire Gouze, Glyn D. Palmer, Steven C. Ghivizzani, Alan J. Grodzinsky et al.
Pages 147-163
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- Anne-Marie Freyria, Michel Becchi
Pages 165-182
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- Gust Verbruggen, Jun Wang, Lai Wang, Dirk Elewaut, Eric M. Veys
Pages 183-208
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- Frédéric De Ceuninck, Audrey Caliez
Pages 209-217
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- Christophe Lesur, Massimo Sabatini
Pages 219-236
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- John S. Mort, Peter J. Roughley
Pages 237-249
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- R. Clark Billinghurst, Fackson Mwale, Anthony Hollander, Mirela Ionescu, A. Robin Poole
Pages 251-273
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- Darryl D. D’Lima, Klaus Kuhn, Martin K. Lotz
Pages 275-289
About this book
Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.