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Peptidomics

Methods and Strategies

  • Book
  • © 2024
  • Latest edition

Overview

Editors:
  1. Michael Schrader

    1. Department of Bioengineering Sciences, Weihenstephan-Tr. University of Applied Science, Freising, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Lloyd D. Fricker

    1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2758)

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Table of contents (26 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Foundations of Peptidomics

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Origins, Technological Advancement, and Applications of Peptidomics

      • Michael Schrader
      Pages 3-47

    3. Two Different Strategies for Stabilization of Brain Tissue and Extraction of Neuropeptides

      • Elva Fridjonsdottir, Anna Nilsson, Lloyd D. Fricker, Per E. Andrén
      Pages 49-60

    4. Mass Spectrometric De Novo Sequencing of Natural Peptides

      • Irina D. Vasileva, Tatiana Yu Samgina, Albert T. Lebedev
      Pages 61-75

    5. Data-Independent Acquisition Peptidomics

      • Leon Bichmann, Shubham Gupta, Hannes Röst
      Pages 77-88

    6. Quantitative Peptidomics: General Considerations

      • Lloyd D. Fricker
      Pages 89-108

    7. Quantitative Peptidomics Using Reductive Methylation of Amines

      • Alexandre K. Tashima, Leandro M. de Castro, Lloyd D. Fricker
      Pages 109-124

    8. Label-Free Quantitation of Endogenous Peptides

      • Md Shadman Ridwan Abid, Haowen Qiu, James W. Checco
      Pages 125-150

    9. Bioinformatics for Prohormone and Neuropeptide Discovery

      • Bruce R. Southey, Elena V. Romanova, Sandra L. Rodriguez-Zas, Jonathan V. Sweedler
      Pages 151-178

    10. Integrating a Multi-label Deep Learning Approach with Protein Information to Compare Bioactive Peptides in Brain and Plasma

      • Alexander G. B. Grønning, Camilla Schéele
      Pages 179-195

  3. Applications Using Non-human Model Systems

    1. Front Matter

      Pages 197-197
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    2. Methods for Intracellular Peptidomic Analysis

      • Rosangela A. S. Eichler, Luiz Felipe Martucci, Leandro M. de Castro, Emer S. Ferro
      Pages 199-212

    3. Neuropeptidomics of Genetically Defined Cell Types in Mouse Brain

      • Lloyd D. Fricker
      Pages 213-225

    4. Nontargeted Identification of d-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS

      • Samuel Okyem, Elena V. Romanova, Hua-Chia Tai, James W. Checco, Jonathan V. Sweedler
      Pages 227-240

    5. Albumen and Yolk Plasma Peptidomics for the Identification and Quantitation of Bioactive Molecules and the Quality Control of Hen Egg Products

      • Simona Arena, Giovanni Renzone, Valentina Ciaravolo, Andrea Scaloni
      Pages 241-254

    6. An Updated Guide to the Identification, Quantitation, and Imaging of the Crustacean Neuropeptidome

      • Wenxin Wu, Lauren Fields, Kellen DeLaney, Amanda R. Buchberger, Lingjun Li
      Pages 255-289

    7. Strategy for the Identification of Host-Defense Peptides in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents

      • J. Michael Conlon, R. Charlotte Moffett, Peter R. Flatt, Jérôme Leprince
      Pages 291-306

    8. Peptidomics of Zebrafish Brain in a 6-OHDA-Induced Neurodegeneration Model

      • Louise O. Fiametti, Felipe Ricardo de Mello, Leandro M. de Castro
      Pages 307-317

    9. Analysis of the Snake Venom Peptidome

      • Solange M. T. Serrano, André Zelanis, Jackson G. Miyamoto, Jackelinne Y. Hayashi, Eduardo S. Kitano, Alexandre K. Tashima
      Pages 319-329
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Keywords

About this book

This updated edition explores essential techniques and newly emerged applications used in the expanding field of peptidomics. The opening chapters describe sample preparation and basic techniques. Subsequent chapters delve into quantitative peptidomics, bioinformatics, deep learning approaches, non-human model organisms, and peptide toxins. The last section includes multiple chapters on applications of peptidomics for human clinical specimens. Written for the highly successful Methods in Molecular Biology series, chapters include overviews and introductions to their respective topics, lists of the necessary materials, reagents, and instrumentation, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and up-to-date, Peptidomics: Methods and Strategies, Second Edition serves as an ideal guide for state-of-the-art approaches in this vital field.

Editors and Affiliations

  • Department of Bioengineering Sciences, Weihenstephan-Tr. University of Applied Science, Freising, Germany

    Michael Schrader

  • Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA

    Lloyd D. Fricker

Bibliographic Information

  • Book Title: Peptidomics

  • Book Subtitle: Methods and Strategies

  • Editors: Michael Schrader, Lloyd D. Fricker

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-3646-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024

  • Hardcover ISBN: 978-1-0716-3645-9Published: 29 March 2024

  • Softcover ISBN: 978-1-0716-3648-0Due: 29 April 2024

  • eBook ISBN: 978-1-0716-3646-6Published: 28 March 2024

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XIV, 506

  • Number of Illustrations: 19 b/w illustrations, 67 illustrations in colour

  • Topics: Protein Science, Chemistry/Food Science, general

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