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Neural Repair

Methods and Protocols

  • Book
  • © 2023

Overview

Editors:
  1. Vardan T. Karamyan

    1. Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ann M. Stowe

    1. Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2616)

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Table of contents (34 protocols)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Stroke Models and Surgical Interventions

    1. Front Matter

      Pages 1-1
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    2. Rodent Stroke Models to Study Functional Recovery and Neural Repair

      • Daimen R. S. Britsch, Nausheen Syeara, Ann M. Stowe, Vardan T. Karamyan
      Pages 3-12

    3. Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation

      • Miguel Alejandro Marin, Amy J. Gleichman, Andrew J. Brumm, S. Thomas Carmichael
      Pages 13-20

    4. A Low-Budget Photothrombotic Rodent Stroke Model

      • Faisal F. Alamri, Serob T. Karamyan, Vardan T. Karamyan
      Pages 21-28

    5. Photothrombotic Model to Create an Infarct in the Hippocampus

      • Elena Blanco-Suárez
      Pages 29-38

    6. Bilateral Carotid Artery Stenosis and Cerebral Blood Flow Outcomes

      • Ifechukwude Joachim Biose, Gregory Jaye Bix
      Pages 39-46

    7. Internal Carotid Artery Stenosis: A Surgical Mouse Model to Study Moyamoya Syndrome

      • Jill M. Roberts, Justin F. Fraser
      Pages 47-54

    8. Modeling Distal Middle Cerebral Artery Occlusion in Neonatal Rodents with Magnetic Nanoparticles or Magnetized Red Blood Cells

      • Jie-Min Jia, Yuxiao Jin
      Pages 55-65

  3. In Vivo and Post-mortem Imaging of Recovery Mechanisms

    1. Front Matter

      Pages 67-67
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    2. In Vivo Imaging of the Structural Plasticity of Cortical Neurons After Stroke

      • Emilia Conti, Francesco Saverio Pavone, Anna Letizia Allegra Mascaro
      Pages 69-81

    3. Measurement of Uninterrupted Cerebral Blood Flow by Laser Speckle Contrast Imaging (LSCI) During the Mouse Middle Cerebral Artery Occlusion Model by an Inverted LSCI Setup

      • Sung-Ha Hong, Andrea Doan, Sean P. Marrelli
      Pages 83-96

    4. Multi-exposure Speckle Imaging for Quantitative Evaluation of Cortical Blood Flow

      • Adam Santorelli, Colin T. Sullender, Andrew K. Dunn
      Pages 97-111

    5. Wide-Field Optical Imaging in Mouse Models of Ischemic Stroke

      • Jonah A. Padawer-Curry, Ryan M. Bowen, Anmol Jarang, Xiaodan Wang, Jin-Moo Lee, Adam Q. Bauer
      Pages 113-151

    6. Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain

      • Vera H. Wielenga, Rick M. Dijkhuizen, Annette Van der Toorn
      Pages 153-168

  4. Methods to Identify Molecular and Immune Mechanisms Supporting Recovery

    1. Front Matter

      Pages 169-169
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    2. Quantitative Spatial Mapping of Axons Across Cortical Regions to Assess Axonal Sprouting After Stroke

      • Mary T. Joy, Samuel P. Bridges, S. Thomas Carmichael
      Pages 171-180

    3. Quantitative Evaluation of Cerebral Microhemorrhages in the Mouse Brain

      • Rudy Chang, Rachita K. Sumbria
      Pages 181-190

    4. In Vivo Evaluation of BBB Integrity in the Post-stroke Brain

      • Yong Zhang, Saeideh Nozohouri, Thomas J. Abbruscato
      Pages 191-203

    5. High-Resolution RNA Sequencing from PFA-Fixed Microscopy Sections

      • Hao Ji, Simon Besson-Girard, Peter Androvic, Buket Bulut, Lu Liu, Yijing Wang et al.
      Pages 205-212
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Keywords

About this book

This detailed collection explores a diverse range of topics related to neural repair and functional recovery following ischemic stroke. Techniques detailed in this book span from basic to emerging approaches used to evaluate hallmarks of neurorepair, including axonal remodeling and dendritic arborization, plasticity and functional connectivity, angiogenesis, neuroinflammation, and recovering cerebral blood flow. In addition, several chapters focus on rodent stroke models and post-stroke functional evaluation, clinically-relevant therapeutic paradigms and co-morbidities, pharmacotherapy and methods of delivery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Neural Repair: Methods and Protocols serves as an ideal guide for the wide community of researchers interested in neurorepair following stroke and other forms of CNS injury.

Editors and Affiliations

  • Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, USA

    Vardan T. Karamyan

  • Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, USA

    Ann M. Stowe

Bibliographic Information

  • Book Title: Neural Repair

  • Book Subtitle: Methods and Protocols

  • Editors: Vardan T. Karamyan, Ann M. Stowe

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2926-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-2925-3Published: 31 January 2023

  • Softcover ISBN: 978-1-0716-2928-4Published: 31 January 2024

  • eBook ISBN: 978-1-0716-2926-0Published: 30 January 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVI, 492

  • Number of Illustrations: 7 b/w illustrations, 118 illustrations in colour

  • Topics: Neurosciences, Neurology

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