Overview
- Editors:
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Dirk J. Ruiter
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Department of Pathology, University Medical Center, Leiden, The Netherlands
Department of Pathology, Faculty of Medicine, University of Leiden, Leiden, The Netherlands
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Kees Welvaart
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Department of Surgical Oncology, University Medical Center, Leiden, The Netherlands
Department of Surgery, University Hospital, Leiden, The Netherlands
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Soldano Ferrone
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Department of Microbiology and Immunology, New York Medical College, Valhalla, USA
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About this book
In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April,. 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M. MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C.
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Table of contents (19 chapters)
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Fundamental Aspects
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- A. W. M. Van Der Kamp, N. G. J. Jaspers
Pages 9-18
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- P. G. Natali, R. Cavaliere, M. Matsui, G. Buraggi, L. Callegaro, S. Ferrone
Pages 19-37
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- J. Brüggen, E.-B. Bröcker, L. Suter, K. Redmann, C. Sorg
Pages 38-56
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Diagnosis and Prognostic Factors
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- F. H. J. Rampen, Ph Rümke
Pages 81-96
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- D. J. Ruiter, S. G. van Duinen, S. O. Warnaar
Pages 112-125
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Treatment
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- K. Welvaart, D. J. A. Van Kampen, J. Hermans, W. Felthuis, J. Van Den Heuvel, P. L. De Jong
Pages 143-164
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- U. Veronesi, R. Bufalino, N. Cascinelli, A. Morabito
Pages 165-180
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- H. Schraffordt Koops, J. Oldhoff, M. Nap, J. W. Oosterhuis, H. Beekhuis
Pages 181-189
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Precursor Lesions
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- W. Bergman, A. Palan, L. N. Went
Pages 227-238
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- D. J. Ruiter, W. Bergman, P. M. Steylen, E. Scheffer
Pages 239-248
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Editors and Affiliations
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Department of Pathology, University Medical Center, Leiden, The Netherlands
Dirk J. Ruiter
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Department of Pathology, Faculty of Medicine, University of Leiden, Leiden, The Netherlands
Dirk J. Ruiter
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Department of Surgical Oncology, University Medical Center, Leiden, The Netherlands
Kees Welvaart
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Department of Surgery, University Hospital, Leiden, The Netherlands
Kees Welvaart
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Department of Microbiology and Immunology, New York Medical College, Valhalla, USA
Soldano Ferrone