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Methods Used in Adenosine Research

  • Book
  • © 1985

Overview

Editors:
  1. David M. Paton

    1. University of Auckland, Auckland, New Zealand

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Synthesis and Measurement of Adenosine and Adenine Nucleotide Analogs

    1. Front Matter

      Pages 1-1
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    2. Synthesis of Adenosine and Adenine Nucleotide Analogs

      • Noel J. Cusack
      Pages 3-20

    3. The Measurement of Adenosine and Adenine Nucleotides in Tissues and Body Fluids

      • Dianne R. Webster
      Pages 21-42

    4. The Demonstration and Measurement of Adenosine Triphosphate Release from Nerves

      • Thomas D. White
      Pages 43-63

  3. Adenosine Metabolism

    1. Front Matter

      Pages 65-65
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    2. The Study of Adenosine Metabolism in Isolated Cells and Tissues

      • J. Frank Henderson
      Pages 67-82

    3. Ectonucleotidases

      • J. D. Pearson
      Pages 83-107

    4. Adenosine Deaminase

      • Ram P. Agarwal
      Pages 109-125

    5. S-Adenosylhomocysteine Hydrolase

      • Peter K. Chiang
      Pages 127-145

    6. Purine Nucleoside Phosphorylase

      • Johanna D. Stoeckler, Robert E. Parks Jr.
      Pages 147-162

  4. Adenosine Transport

    1. Front Matter

      Pages 163-163
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    2. Measurement and Inhibition of Membrane Transport of Adenosine

      • Alan R. P. Paterson, Eric R. Harley, Carol E. Cass
      Pages 165-180

    3. The Use of Ligands in the Study of the Nucleoside-Transport Complex

      • James D. Young, Simon M. Jarvis
      Pages 181-190

  5. Classification and Identification of Receptors for Adenosine and Adenine Nucleotides

    1. Front Matter

      Pages 191-191
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    2. The Classification of Receptors for Adenosine and Adenine Nucleotides

      • Geoffrey Burnstock, Noel J. Buckley
      Pages 193-212

    3. The Pharmacologic Estimation of Potencies of Agonists and Antagonists in the Classification of Adenosine Receptors

      • Terry P. Kenakin, H. J. Leighton
      Pages 213-237

    4. Use of Radioligands in the Identification, Classification, and Study of Adenosine Receptors

      • Ulrich Schwabe
      Pages 239-278

    5. Use of Photoaffinity Labels as P2-Purinoceptor Antagonists

      • Jeffrey S. Fedan, G. Kurt Hogaboom, John P. O’Donnell, David P. Westfall
      Pages 279-292

    6. Use of Structure-Activity Relationships in the Study of Adenosine Receptors

      • R. A. Olsson, R. D. Thompson, S. Kusachi
      Pages 293-304
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Keywords

About this book

In their classic paper in 1929, Drury and Szent-Gyorgyi described a number of the important cardiovascular actions of adenosine. Another thirty years were to pass before the possible physiological role of adenosine in coronary vasodilation was studied by Berne and others. Since then, there has been a tremendous increase in research into the actions of adenosine. Workers from many disciplines have employed a wide variety of techniques, since adenosine is a product of and a substrate for a number of metabolic pathways, is transported into cells, and acts at discrete receptor sites to modulate the activity of adenylate cyclase and to produce important actions on many cells and tissues including platelets, adipo­ cytes, heart, blood vessels, and other smooth muscles. International symposia on the actions of adenosine were held in 1978, 1981, and 1982, and the proceedings of these symposia have been published (Baer and Drummond, 1979; Daly et at., 1983; Berne et at., 1983). Since it is not the primary purpose of the present volume to review our current understanding of the nu­ merous actions of adenosine, these volumes should be consulted for such details. Rather, the present volume has been planned to provide both graduate students and investigators in pharmacology and related disciplines with a summary of some of the methods now available for the study of the actions of adenosine and, in particular, to highlight their possible uses and limitations.

Editors and Affiliations

  • University of Auckland, Auckland, New Zealand

    David M. Paton

Bibliographic Information

  • Book Title: Methods Used in Adenosine Research

  • Editors: David M. Paton

  • DOI: https://doi.org/10.1007/978-1-4684-4886-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1985

  • Softcover ISBN: 978-1-4684-4888-7Published: 21 January 2013

  • eBook ISBN: 978-1-4684-4886-3Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XVI, 384

  • Number of Illustrations: 2 b/w illustrations

  • Topics: Pharmacology/Toxicology

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