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About this book
It is a pleasure to introduce Volume 5 in the Methods in Pharmacology series. In 1971, Volume 1 of this series was published while I was Head of the Division of Myocardial Biology in the Department of Pharmacology at Baylor College of Medicine in Houston, Texas. I dedicated that first volume to Sir Henry Hallet Dale, who died on July 23, 1968. In the Preface I pointed out that many of the pharmacological advancements that occurred during the last century were direct descendants from the classic paper published in 1910 by Professor Dale and his colleague, Dr. Barger. In this paper, the concept of "specific receptor sites" was introduced by the statement that "the relationship of the recepted mechanism to the base [i. e. , drug base] may well be one of solid solution of adsorption and, therefore, more analogous to that of an enzyme to its substrate . . . . " I also pointed out at that time that the search for drug receptors continues and that fundamental knowledge of the nature of receptors and drug-receptor interaction will eventually lead to a rational approach to drug design. Since 1971, the study of receptors and their interaction with specific chemical substances has continued at an accelerated pace and this is due, in particular, to the introduction of new and exciting methodologies. The death last year of Professor Raymond P. Ahl quist, who pioneered the introduction of specific adrenergic receptors, represents the close of yet another era.
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Table of contents (13 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Myocardial Biology
Editors: Arnold Schwartz
DOI: https://doi.org/10.1007/978-1-4684-4778-1
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 1984
Softcover ISBN: 978-1-4684-4780-4Published: 27 October 2013
eBook ISBN: 978-1-4684-4778-1Published: 14 March 2013
Edition Number: 1
Number of Pages: XII, 236
Number of Illustrations: 61 b/w illustrations
Topics: Pharmacology/Toxicology