Overview
Offers updates for some original chapters and new contributions
Discusses the effects of ferroptosis cell death on metabolism
Explores the relevance of ferroptosis cell death for human diseases
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Table of contents (22 chapters)
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Front Matter
Keywords
About this book
This updated and expanded volume gives new insights on ferroptosis – an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.
Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2.
This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.
Editors and Affiliations
About the editor
Daolin Tang
Dr Tang’s work chiefly focuses on designing and conducting molecular, cellular, and animal studies to investigate the mechanisms of damage-associated molecular pattern molecule (DAMP) release and activity in autophagy and cell death, and to evaluate novel drug candidates for the treatment of various inflammatory diseases, including cancer. His past contributions to biomedical science include the initial description of the role of high-mobility group box 1 (HMGB1), a classical DAMP, in autophagy. His recent contributions to DAMP biology include the identification of a novel function and activity of HMGB1 in infection and sterile inflammation. More recently, he has also identified a number of regulators of necroptosis, ferroptosis, pyroptosis, and alkaliptosis. In summary, Dr Tang is an outstanding investigator with a proven track record of innovation and achievement in the fields of DAMP, autophagy, and cell death.
Bibliographic Information
Book Title: Ferroptosis in Health and Disease
Editors: Daolin Tang
DOI: https://doi.org/10.1007/978-3-031-39171-2
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-39170-5Published: 29 October 2023
Softcover ISBN: 978-3-031-39173-6Due: 12 November 2024
eBook ISBN: 978-3-031-39171-2Published: 28 October 2023
Edition Number: 2
Number of Pages: VIII, 490
Number of Illustrations: 54 illustrations in colour
Topics: Cell Physiology, Apoptosis, Human Physiology, Protein Science, Oxidative Stress