Overview
- Complete overview of Chagas disease; its transmission, pathogenesis, diagnosis and treatment
- Discusses molecular diagnosis of the disease and the use of proteomic biomarkers in clinical practice
- Explores possible future pharmacological developments for the treatment of infected individuals
Part of the book series: Birkhäuser Advances in Infectious Diseases (BAID)
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About this book
Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals.
This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area.Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com.
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Table of contents (16 chapters)
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Front Matter
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Overview
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Front Matter
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Epidemiology
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Front Matter
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Diagnosis
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Front Matter
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Clinical Aspects
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Front Matter
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Treatment
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Editors and Affiliations
About the editors
Dr. Jaime Marcelo Altcheh is head of the Parasitology Service and independent researcher at Ricardo Gutierrez Children’s hospital in Buenos Aires, Argentina.
Hector Freilij is a medical consultant at the same institution. Both are experts for tropical and especially trypanosomal diseases and have extensive worldwide collaborations and publications in international journals.
Hector Freilij is a medical consultant at the same institution. Both are experts for tropical and especially trypanosomal diseases and have extensive worldwide collaborations and publications in international journals.
Bibliographic Information
Book Title: Chagas Disease
Book Subtitle: A Clinical Approach
Editors: Jaime Marcelo Altcheh, Hector Freilij
Series Title: Birkhäuser Advances in Infectious Diseases
DOI: https://doi.org/10.1007/978-3-030-00054-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-00053-0Published: 25 September 2019
eBook ISBN: 978-3-030-00054-7Published: 09 September 2019
Series ISSN: 2504-3811
Series E-ISSN: 2504-3838
Edition Number: 1
Number of Pages: XII, 356
Number of Illustrations: 14 b/w illustrations, 34 illustrations in colour
Topics: Molecular Medicine, Parasitology, Infectious Diseases