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Leukemia Stem Cells in Hematologic Malignancies

  • Book
  • © 2019

Overview

Editors:
  1. Haojian Zhang

    1. Medical Research Institute, Wuhan University, Wuhan, China

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  2. Shaoguang Li

    1. Department of Medicine, University of Massachusetts Medical School, Worcester, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Introduces readers to the biology of leukemia stem cells
  • Emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies
  • Covers the molecular signatures of leukemia stem cells

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1143)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Signaling Pathways in Leukemic Stem Cells

    • Lindsay M. Gurska, Kristina Ames, Kira Gritsman
    Pages 1-39

  3. Cellular and Molecular State of Myeloid Leukemia Stem Cells

    • Xueqin Xie, Mengdie Feng, Qifan Wang, Jiazhen Wang, Rong Yin, Yicun Li et al.
    Pages 41-57

  4. Metabolic Regulations in Hematopoietic Stem Cells

    • Dan Huang, Chiqi Chen, Xiaoxin Hao, Hao Gu, Li Xie, Zhuo Yu et al.
    Pages 59-74

  5. RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis

    • Hengyou Weng, Huilin Huang, Jianjun Chen
    Pages 75-93

  6. Leukemia Stem Cells in the Pathogenesis, Progression, and Treatment of Acute Myeloid Leukemia

    • Kanak Joshi, Lei Zhang, Peter Breslin S.J., Jiwang Zhang
    Pages 95-128

  7. Tissue “Hypoxia” and the Maintenance of Leukemia Stem Cells

    • Persio Dello Sbarba, Giulia Cheloni
    Pages 129-145

  8. DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells

    • Wenjun Zhang, Guangming Wang, Aibin Liang
    Pages 147-171

  9. Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells

    • Jing Xu, Xiaohang Hang, Baohong Wu, Chong Chen, Yu Liu
    Pages 173-189

  10. Leukemia Stem Cells in Chronic Myeloid Leukemia

    • Yi Shan, Ngoc DeSouza, Qiang Qiu, Shaoguang Li
    Pages 191-215

  11. Cellular Immunotherapy in the Treatment of Hematopoietic Malignancies

    • Satoko Matsueda, Thinle Chodon, Richard C. Koya
    Pages 217-229
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Keywords

About this book

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Editors and Affiliations

  • Medical Research Institute, Wuhan University, Wuhan, China

    Haojian Zhang

  • Department of Medicine, University of Massachusetts Medical School, Worcester, USA

    Shaoguang Li

About the editors

Dr. Haojian Zhang
Dr. Shaoguang Li

Bibliographic Information

  • Book Title: Leukemia Stem Cells in Hematologic Malignancies

  • Editors: Haojian Zhang, Shaoguang Li

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-13-7342-8

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-7341-1Published: 05 August 2019

  • Softcover ISBN: 978-981-13-7344-2Published: 14 August 2020

  • eBook ISBN: 978-981-13-7342-8Published: 23 July 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 229

  • Number of Illustrations: 3 b/w illustrations, 37 illustrations in colour

  • Topics: Cancer Research, Stem Cells

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