Cell Biology of the Ovary

1. Front Matter

   Pages i-viii

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2. Reconstitution of Germ Cell Development In Vitro

   • Shihori Yokobayashi, Mitinori Saitou

   Pages 1-19

3. The Role of Hedgehog-BMP4 Signaling in the Patterning of Coelomic Mesoderm and the Onset of Gonadogenesis

   • Takashi Yoshino

   Pages 21-33

4. Regulation of Metabolic Pathways in Steroidogenic Cells by Ad4BP/SF-1

   • Ken-ichirou Morohashi, Miki Inoue, Bing Li, Takashi Baba

   Pages 35-43

5. Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract

   • Annie Ng, Nick Barker

   Pages 45-59

6. Tumor-Initiating Cells in Ovarian Cancer

   • Sharmila A. Bapat

   Pages 61-71

7. Emerging Role of CD44 Variant 6 in Driving the Metastatic Journey of Ovarian Cancer Stem Cells

   • Takeshi Motohara, Hidetaka Katabuchi

   Pages 73-88

8. Clinical Management of Primary Ovarian Insufficiency

   • Yoshinori Okamura

   Pages 89-99

9. Rescue for Primary Ovarian Insufficiency

   • Kyu Sup Lee

   Pages 101-112

10. Current Status of Ovarian Tissue Vitrification as a Fertility Preservation for the Young Cancer Patients

    • Nao Suzuki

    Pages 113-121

11. Molecular Pathogenesis of Ovarian Cancer: An Inextricable Maze

    • Masaki Mandai

    Pages 123-134

12. Clinical Management of Epithelial Ovarian Cancer

    • Yusuke Kobayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki

    Pages 135-151

13. Molecular Targeted Therapy for Epithelial Ovarian Cancer

    • Hironori Tashiro, Hidetaka Katabuchi

    Pages 153-166

This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer.  

• Ovarian tissue
• Ovarian cancer
• Stem cell
• Ovarian surface epithelial cells
• Primordial germ cells

     

• Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

  Hidetaka Katabuchi, Takashi Ohba, Takeshi Motohara

Dr. Hidetaka Katabuchi,

Professor and Chairman,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

Dr. Takashi Ohba,

Associate Professor,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

  

Dr. Takeshi Motohara,

Assistant Professor,

Department of Obstetrics and Gynecology,

Faculty of Life Sciences,

Kumamoto University

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