Developmental Origins of Health and Disease (DOHaD)

1. Front Matter

   Pages i-vii

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2. Biological Basis

   1. Front Matter

      Pages 1-1

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   2. One-Carbon Metabolism and Lipid Metabolism in DOHaD

      • Hideoki Fukuoka, Takeo Kubota

      Pages 3-9

   3. Novel Models of Epigenetic Gene Regulation in the Nutritional Environment

      • Kazuki Mochizuki, Natsuyo Hariya, Takeo Kubota

      Pages 11-18

   4. Epigenetic Switching and Neonatal Nutritional Environment

      • Koshi Hashimoto, Yoshihiro Ogawa

      Pages 19-25

3. Disease and Environment

   1. Front Matter

      Pages 27-27

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   2. Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)

      • Hiroaki Itoh, Naohiro Kanayama

      Pages 29-39

   3. Fetal Origins of Hypertension

      • Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita

      Pages 41-48

   4. Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD Theory

      • Takahiro Nemoto, Yoshihiko Kakinuma

      Pages 49-59

4. Transgenerational Mechanism and Its Consequences

   1. Front Matter

      Pages 61-61

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   2. Placental Development and Nutritional Environment

      • Kosuke Taniguchi, Tomoko Kawai, Kenichiro Hata

      Pages 63-73

   3. Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm

      • Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi

      Pages 75-81

5. Clinical Significance

   1. Front Matter

      Pages 83-83

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   2. Preemptive Epigenetic Medicine Based on Fetal Programming

      • Takeo Kubota

      Pages 85-95

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

• Epigenome
• Pre-emptive medicine
• Metabolic disease
• Maternal under-nutrition
• Nutritional environment

• Faculty of Child Studies, Seitoku University, Matsudo, Japan

  Takeo Kubota

• Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan

  Hideoki Fukuoka

Takeo Kubota

Faculty of Child Studies, Seitoku University, Chiba, Japan

Hideoki Fukuoka

Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

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