Overview
- Provides a comprehensive knowledge of RNA activation
- Chapters highlight recent advances in specific topics
- Refers to several kinds of cancer
- Contributed by world recognized experts in this field
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 983)
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Table of contents (16 chapters)
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Front Matter
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RNA Activation Guided by Other Small RNAs
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Front Matter
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Developing RNAa-Based Therapeutics
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Front Matter
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Keywords
About this book
This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).
With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: RNA Activation
Editors: Long-Cheng Li
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-10-4310-9
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-4309-3Published: 03 July 2017
Softcover ISBN: 978-981-13-5102-0Published: 09 December 2018
eBook ISBN: 978-981-10-4310-9Published: 19 June 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIV, 239
Number of Illustrations: 7 b/w illustrations, 38 illustrations in colour
Topics: Gene Expression, Biochemistry, general, Cell Biology, Molecular Medicine, Cancer Research