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  • © 2015

Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring

An Introduction

Editors:

  • The only general introductory book on CNAPS
  • Methodology discussed and preferred methods delineated
  • Determination of early markers and prognosis of disease and treatment monitoring
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine (APPPM, volume 5)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xix
  2. Background

    1. Front Matter

      Pages 1-1
    2. The Biology of CNAPS

      • Peter B. Gahan
      Pages 15-41
  3. Methodology

    1. Front Matter

      Pages 43-43
    2. Pre-analytical Requirements for Analyzing Nucleic Acids from Blood

      • Safia El Messaoudi, Alain R. Thierry
      Pages 45-69
    3. Circulating DNA and miRNA Isolation

      • Alain R. Thierry, Safia El Messaoudi, Evelyne Lopez-Crapez
      Pages 71-87
    4. Detection of Genetic Alterations by Nucleic Acid Analysis: Use of PCR and Mass Spectroscopy-Based Methods

      • Florent Mouliere, Alain R. Thierry, Christian Larroque
      Pages 89-111
    5. Genomic Approaches to the Analysis of Cell Free Nucleic Acids

      • Wenying Pan, Stephen R. Quake
      Pages 113-139
  4. Applications

    1. Front Matter

      Pages 141-141
    2. CNAPS and General Medicine

      • Heidi Schwarzenbach
      Pages 143-163
    3. Fetal CNAPS – DNA/RNA

      • Stephanie Cheuk Yin Yu
      Pages 165-212
    4. Circulating Nucleic Acids and Diabetes Mellitus

      • Asif Butt, Ramasamyiyer Swaminathan
      Pages 213-237
    5. Extracellular Nucleic Acids and Cancer

      • Michael Fleischhacker, Bernd Schmidt
      Pages 239-293
    6. Other Body Fluids as Non-invasive Sources of Cell-Free DNA/RNA

      • Lisa Hui, Jill L. Maron, Peter B. Gahan
      Pages 295-323
    7. CNAPS in Therapy Monitoring

      • Stefan Holdenrieder
      Pages 325-367
  5. Other Aspects

    1. Front Matter

      Pages 369-369
    2. Quality Assurance

      • Rob Elles, Simon Patton, Outi Kamarainen, Zandra Deans
      Pages 371-380
    3. Societal Aspects: Ethics

      • Celine Lewis, Lyn S. Chitty
      Pages 381-398
  6. Back Matter

    Pages 399-471

About this book

DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids.

The areas covered in this volume include:

·      Background and general biology of circulating nucleic acids

·      Methodology

·      Applications of circulating nucleic acids

·      Quality Assurance

·      Ethics

Editors and Affiliations

  • Anatomy & Human Sciences, King's College London, London, United Kingdom

    Peter B. Gahan

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access