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  • © 2014

Mitochondria: The Anti- cancer Target for the Third Millennium

  • Examines the importance of mitochondria as a potential molecular target for the treatment of a variety of human pathologies, in particular cancer
  • Covers the basics as well as more focused topics, such as interaction with drugs, emerging targets in pathology and platforms for the development of novel drugs
  • Features chapters written by experts in the area of mitochondrial research
  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
  2. Mitochondrion: A Novel Center for Cancer Cell Signaling

    • Sumitra Miriyala, Aaron K. Holley, Daret K. St. Clair
    Pages 1-38
  3. Exploiting BH3 Mimetics for Cancer Therapy

    • Donat Kögel
    Pages 39-58
  4. Regulation of Mitochondrial Function by MicroRNA

    • Marco Tomasetti, Lan-Feng Dong, Jiri Neuzil
    Pages 59-80
  5. Mitochondrial Complex II in Cancer

    • Katarina Kluckova, Jiri Neuzil, Jakub Rohlena
    Pages 81-104
  6. Exploiting Celecoxib in Cancer Therapy

    • Verena Jendrossek
    Pages 105-133
  7. Targeting Mitochondria of Cancer Cells: Mechanisms and Compounds

    • Gang Chen, Helene Pelicano, Marcia A. Ogasawara, Feng Wang, Peng Huang
    Pages 183-210
  8. Targets and Strategies for the Mitochondrial Assault on Cancer

    • Lucia Biasutto, Ildikò Szabò, Mario Zoratti
    Pages 211-264
  9. Emerging Anti-cancer Targets in Mitochondria

    • Petr Ježek, Katarína Smolková, AleÅ¡ Dvořák, Tomáš Olejár
    Pages 265-290
  10. Relevance of Mitochondrial Functions and Plasticity in Tumor Biology

    • Emilie Obre, Nadège Bellance, Caroline Jose, Giovanni Benard, Karine Nouette-Gaulain, Rodrigue Rossignol
    Pages 291-325
  11. Crosstalk Between p53 and Mitochondrial Metabolism

    • Koji Itahana, Shazib Pervaiz
    Pages 327-348
  12. The Progression of Cardiomyopathy in the Mitochondrial Disease, Friedreich’s Ataxia

    • Samantha Ting, Michael Li-Hsuan Huang, Sutharshani Sivagurunathan, Des R. Richardson
    Pages 349-377
  13. Back Matter

    Pages 379-382

About this book

This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Editors and Affiliations

  • School of Medical Science, Griffith University, Southport, Australia

    Jiri Neuzil

  • School of Medicine, National University of Singapore, Singapore, Singapore

    Shazib Pervaiz

  • Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany

    Simone Fulda

Bibliographic Information

  • Book Title: Mitochondria: The Anti- cancer Target for the Third Millennium

  • Editors: Jiri Neuzil, Shazib Pervaiz, Simone Fulda

  • DOI: https://doi.org/10.1007/978-94-017-8984-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Hardcover ISBN: 978-94-017-8983-7Published: 12 June 2014

  • Softcover ISBN: 978-94-024-0349-7Published: 17 September 2016

  • eBook ISBN: 978-94-017-8984-4Published: 26 May 2014

  • Edition Number: 1

  • Number of Pages: VIII, 382

  • Number of Illustrations: 4 b/w illustrations, 41 illustrations in colour

  • Topics: Cancer Research, Oncology, Biomedicine general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access