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A Structural Perspective on Respiratory Complex I

Structure and Function of NADH:ubiquinone oxidoreductase

  • Book
  • © 2012

Overview

Editors:
  1. Leonid Sazanov

    1. , Mitochondrial Biology Unit, Medical Research Council, Cambridge, United Kingdom

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  • Concise review of current state-of-the-art in research on respiratory complex I
  • The first book entirely devoted to complex I, a central enzyme in bioenergetics
  • Recent breakthroughs in structure elucidation finally allow some understanding of the mechanism
  • Mutations leading to common and severe human disorders are discussed

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
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  2. Structure and Mechanism of Complex I

    1. Front Matter

      Pages 1-1
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  3. Structure and mechanism of complex I

    1. Structure of Complex I

      • Rouslan G. Efremov, Leonid Sazanov
      Pages 3-21

    2. On the Mechanism of the Respiratory Complex I

      • Thorsten Friedrich, Petra Hellwig, Oliver Einsle
      Pages 23-59

    3. Iron–Sulfur Clusters in Complex I

      • Eiko Nakamaru-Ogiso
      Pages 61-79

    4. Current Topics of the Inhibitors of Mitochondrial Complex I

      • Hideto Miyoshi
      Pages 81-98

    5. My Fifty Years Association with Complex I Study

      • Tomoko Ohnishi
      Pages 99-105

  4. Evolution of Complex I

    1. Front Matter

      Pages 107-107
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  5. Evolution of complex I

    1. The Evolutionary Relationship Between Complex I and [NiFe]-Hydrogenase

      • Anne Volbeda, Juan C. Fontecilla-Camps
      Pages 109-121

    2. Recruitment of the Antiporter Module – A Key Event in Complex I Evolution

      • Vamsi Krishna Moparthi, Cecilia Hägerhäll
      Pages 123-143

  6. Mutations in Complex I Subunits and Medical Implications

    1. Front Matter

      Pages 145-145
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  7. Mutations in complex I subunits and medical implications

    1. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach

      • Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, Akemi Matsuno-Yagi
      Pages 147-169

    2. Cellular Consequences of mtDNA-Encoded Mutations in NADH:Ubiquinone Oxidoreductase

      • Mina Pellegrini, Jan A. M. Smeitink, Peter H. G. M. Willems, Werner J. H. Koopman
      Pages 171-189

  8. Subunit Composition and Assembly of Mitochondrial Complex I

    1. Front Matter

      Pages 191-191
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  9. Subunit composition and assembly of mitochondrial complex I

    1. The Assembly of Human Complex I

      • Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans
      Pages 193-217

    2. Complexes I in the Green Lineage

      • Claire Remacle, Patrice Hamel, Véronique Larosa, Nitya Subrahmanian, Pierre Cardol
      Pages 219-244

  10. Supercomplexes in Mitochondria

    1. Front Matter

      Pages 245-245
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  11. Supercomplexes in mitochondria

    1. Supramolecular Organization of the Respiratory Chain

      • Janet Vonck
      Pages 247-277

  12. Back Matter

    Pages 279-286
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Keywords

About this book

The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

Editors and Affiliations

  • , Mitochondrial Biology Unit, Medical Research Council, Cambridge, United Kingdom

    Leonid Sazanov

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