Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

1. Front Matter

   Pages i-xvi

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2. Cytochrome P450 2E1: Its Clinical Aspects and a Brief Perspective on the Current Research Scenario

   • Aparajita Dey

   Pages 1-104

3. Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity

   • Arthur I. Cederbaum

   Pages 105-130

4. The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis

   • Helmut K. Seitz, Xiang-Dong Wang

   Pages 131-143

5. The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome

   • Samuel W. French

   Pages 145-164

6. Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease

   • Ann K. Daly

   Pages 165-175

7. CYP2E1-Catalyzed Alcohol Metabolism: Role of Oxidant Generation in Interferon Signaling, Antigen Presentation and Autophagy

   • Natalia A. Osna, Terrence M. Donohue Jr.

   Pages 177-197

8. CYP2E1, Oxidative Stress, Post-translational Modifications and Lipid Metabolism

   • M. Raj Lakshman, Mamatha Garige, Maokai A. Gong, Leslie Leckey, Ravi Varatharajalu, Robert S. Redman et al.

   Pages 199-233

9. The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System

   • Claire Heit, Hongbin Dong, Ying Chen, David C. Thompson, Richard A. Deitrich, Vasilis K. Vasiliou

   Pages 235-247

10. Back Matter

    Pages 249-256

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The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

• Cytochrome P4502E1
• diseases
• drugs
• injury
• reactive oxygen species

• , AU-KBC Research Centre, Anna University, Chennai, India

  Aparajita Dey

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