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Phosphoinositides I: Enzymes of Synthesis and Degradation

  • Book
  • © 2012

Overview

Editors:
  1. Tamas Balla

    1. , NICHD, National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Matthias Wymann

    1. , Cancer- and Immunobiology, University of Basel, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  3. John D. York

    1. , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • In depth discussion of the state of the art of phosphoinositide research
  • Experts in the field discussing the 'hot' topics in phosphoinositide research
  • A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 58)

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Table of contents (9 chapters)

  1. Front Matter

    Pages 1-1
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  2. The Phosphatidylinositol 4-Kinases: Don’t Call it a Comeback

    • Shane Minogue, Mark G. Waugh
    Pages 1-24

  3. PIP Kinases from the Cell Membrane to the Nucleus

    • Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan, Richard Anderson
    Pages 25-59

  4. The Phospholipase C Isozymes and Their Regulation

    • Aurelie Gresset, John Sondek, T. Kendall Harden
    Pages 61-94

  5. Phosphoinositide 3-Kinases—A Historical Perspective

    • Alex Toker
    Pages 95-110

  6. PI3Ks—Drug Targets in Inflammation and Cancer

    • Matthias Wymann
    Pages 111-181

  7. Phosphoinositide 3-Kinases in Health and Disease

    • Alessandra Ghigo, Fulvio Morello, Alessia Perino, Emilio Hirsch
    Pages 183-213

  8. Phosphoinositide Phosphatases: Just as Important as the Kinases

    • Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic, Christina A. Mitchell
    Pages 215-279

  9. The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease

    • Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal, Clare G. Fedele, Christina A. Mitchell, Nicholas R. Leslie
    Pages 281-336

  10. Erratum

    • Tamas Balla, Matthias Wymann, John D. York
    Pages 337-337

  11. Back Matter

    Pages 334-334
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Keywords

About this book

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Editors and Affiliations

  • , NICHD, National Institutes of Health, Bethesda, USA

    Tamas Balla

  • , Cancer- and Immunobiology, University of Basel, Basel, Switzerland

    Matthias Wymann

  • , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA

    John D. York

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