Modulation of Presynaptic Calcium Channels

1. Front Matter

   Pages i-xii

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2. Overview

   1. Front Matter

      Pages 1-1

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   2. Overview: Spatial and Temporal Regulation of Ca2+ Channels

      • Sumiko Mochida

      Pages 3-26

3. Interaction Partners of Calcium Channels

   1. Front Matter

      Pages 27-27

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   2. Neuronal Functions of Auxiliary Calcium Channel Subunits

      • Gerald J. Obermair, Bernhard E. Flucher

      Pages 29-59

   3. Reciprocal Regulation of Neuronal Calcium Channels by Synaptic Proteins

      • Norbert Weiss, Gerald W. Zamponi

      Pages 61-78

   4. Molecular Architecture of Ca2+ Channel Complexes Organized by CaVβ Subunits in Presynaptic Active Zones

      • Akito Nakao, Mitsuru Hirano, Yoshinori Takada, Shigeki Kiyonaka, Yasuo Mori

      Pages 79-99

   5. Control of CaV2 Calcium Channels and Neurosecretion by Heterotrimeric G Protein Coupled Receptors

      • Mark L. Jewell, Kevin P. M. Currie

      Pages 101-130

   6. RGK Small GTPases and Regulation of CaV2 Channels

      • Pierre Charnet, Frédérique Scamps, Matthieu Rousset, Claudine Menard, Michel Bellis, Thierry Cens

      Pages 131-149

   7. Protein Interaction Partners of Cav2.3 R-Type Voltage-Gated Calcium Channels

      • Maxine Dibué, Etienne E. Tevoufouet, Felix Neumaier, Andreas Krieger, Alexandra Kiel, Dimitar Evdokimov et al.

      Pages 151-174

   8. Voltage-Gated Calcium Channel Signaling to the Nucleus

      • Michel Bellis, Thierry Cens, Pierre Charnet, Matthieu Rousset

      Pages 175-198

4. Mechanisms of Studying Calcium Channel Effects

   1. Front Matter

      Pages 199-199

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   2. Presynaptic Ca2+ Influx and Its Modulation at Auditory Calyceal Terminals

      • Holger Taschenberger, Kun-Han Lin, Shuwen Chang

      Pages 201-221

   3. Use of Synthetic Ca2+ Channel Peptides to Study Presynaptic Function

      • Giovanna Bucci, Sumiko Mochida, Gary Stephens

      Pages 223-240

5. Calcium Channel Therapeutics

   1. Front Matter

      Pages 241-241

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   2. Impact of a Loss-of-Function P/Q Type Ca2+ Channel Mutation on Excitatory Synaptic Control of Cerebellar Purkinje Neurons

      • David D. Friel

      Pages 243-261

   3. CaV2.1 (P/Q) Voltage Activated Ca2+ Channels and Synaptic Transmission in Genetic and Autoimmune Diseases

      • Osvaldo D. Uchitel

      Pages 263-288

   4. Splicing and Editing to Customize CaV Channel Structures for Optimal Neural Function

      • Hua Huang, Juejin Wang, Tuck Wah Soong

      Pages 289-318

   5. Presynaptic Calcium Channels as Drug Targets for Pain

      • Peter J. Cox, Edward B. Stevens

      Pages 319-343

   6. Sensory Pathway Modulation by Calcium Channel α2δ1 Subunit

      • Chunyi Zhou, Z. David Luo

      Pages 345-362

This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.

• CNS disease
• calcium channels
• genetic disease
• presynaptic mechanisms
• synaptic transmission

• , School of Pharmacy, University of Reading, Reading, United Kingdom

  Gary Stephens

• , Department of Physiology, Tokyo Medical University, Tokyo, Japan

  Sumiko Mochida

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