Insulin & Related Proteins — Structure to Function and Pharmacology

1. Front Matter

   Pages i-xiv

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2. How Insulin Came from Heidelberg to Aachen and Why it Took Five Years

   • H. Zahn

   Pages 1-5

3. Insulin at the German Wool Research Institute-Retrospect and Outlook

   • D. Brandenburg

   Pages 7-28

4. Insulin: Sequence, Structure and Function - A Story of Surprises

   • G. G. Dodson, J. L. Whittingham

   Pages 29-39

5. The Association/Dissociation Equilibria of Insulin in the Presence of Metal Ions: A Fluorescence Energy Transfer and Circular Dichroism Study

   • U. Hassiepen, J. Stahl, B. Motzka, M. Federwisch

   Pages 41-51

6. Self-Association of Insulin Reconsidered

   • A. Wollmer, T. Mülders

   Pages 53-65

7. Self-Association of Insulin Reconsidered

   • T. Mülders, A. Wollmer

   Pages 67-76

8. T-R Transition

   • A. Wollmer

   Pages 77-89

9. Comparison of Conformational Transitions in Proteins

   • P. KRÜGER

   Pages 91-101

10. Activities of Insulin Analogues at Position A8 are Uncorrelated with Thermodynamic Stability

    • M. A. Weiss, Q. -X. Hua, W. Jia, S. H. Nakagawa, Y. -C. Chu, P. G. Katsoyannis

    Pages 103-119

11. Relationships between the Structure of Insulin and its Physiological Effects

    • R. H. Jones, F. Shojaee-Moradie

    Pages 121-130

12. Structure-Function Relationships of Insulin and Insulin-Like Growth factor-I Receptor Binding

    • P. De Meyts, J. Whittaker

    Pages 131-149

13. Structural Relationships between Members of the Insulin Receptor Family

    • C. W. Ward, T. P. J. Garrett, N. M. McKern, L. G. Sparrow, M. J. Frenkel

    Pages 151-164

14. Insulin Interaction with Minimized Receptors and Binding Proteins

    • C. Kristensen, A. S. Andersen

    Pages 165-176

15. Identification of Susceptibility Loci for Obesity, Insulin Resistance, and Hyperglycemia in a Backcross Model of New Zealand Obese (NZO) and Lean SJL Mice

    • L. Plum, K. Giesen, R. Kluge, H. -G. Joost

    Pages 177-188

16. Activation Mechanism of Fibroblast Growth Factor Receptor Tyrosine Kinase Revealed by Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Fibroblast Growth Factor and Heparin

    • L. Pellegrini, D. F. Burke, T. L. Blundell

    Pages 189-200

17. IL-6 Type Cytokine Receptor Complexes

    • J. Grötzinger

    Pages 201-212

18. Inhibition of Growth Factor Stimulated Pathways for the Treatment of Prostate Cancer

    • F. Bost, Y. -M. Yang, C. Liu, W. Charbono, N. Dean, R. Mckay et al.

    Pages 213-231

19. Molecular Dynamics Simulations of Carbonmonoxy Myoglobin and Calculations of Heme Circular Dichroism

    • R. W. Woody, C. Kiefl, N. Sreerama, Y. Lu, Y. Qiu, J. A. Shelnutt

    Pages 233-248

20. Back Matter

    Pages 249-252

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This book contains contributions presented at the last of the Alcuin Symposia, held in April 2000, as a Festschrift to honour Prof. Axel Wollmer on the occasion of his retirement from the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen. The Alcuin Symposia were initially held alternatively in York and Aachen, in recent years in Aachen only, as joint workshops on insulin between the groups of Prof. Guy Dodson in York and the groups of Profs Dietrich Brandenburg and Axel Wollmer in Aachen. The Symposium was named after Alcuin, an Anglo-Latin poet, educator and cleric from York, who was invited to join the court of Charlemagne at Aachen. Alcuin’s first 50 years were spent in Yorkshire, were he was first a pupil, later headmaster of the cathedral school of York, the most renowned of its day. Charlemagne was gathering at Aachen the leading Irish, English and Italian scholars of the age. Alcuin was appointed head of the Palatine school, where Charlemagne himself, his family, his friends, and his friends’s sons were taught. Alcuin introduced the traditions of Anglo-Saxon humanism into Western Europe and was the foremost scholar of the revival of learning known as the Carolingian Renaissance. He also promoted the use of the beautiful Carolingian minuscule script, the ancestor of modern Roman typefaces.

• G proteins
• growth factor
• insulin
• insulin resistance
• insulin-like
• diabetes

• Novo Nordisk Pharma GmbH, Mainz, Germany

  Markus Leyck Dieken

• Institut für Biochemie, RWTH, Aachen, Germany

  Matthias Federwisch

• Hagedorn Research Laboratory, Gentofte, Denmark

  Pierre Meyts

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