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Risk-Benefit Analysis in Drug Research

Proceedings of an International Symposium held at the University of Kent at Canterbury, England, 27 March 1980

  • Conference proceedings
  • © 1981

Overview

Editors:
  1. J. F. Cavalla

    1. Wyeth Laboratories, Taplow, Maidenhead, Berkshire, England

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Table of contents (16 papers)

  1. Front Matter

    Pages i-x
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  2. Risk-benefit in medicine

    • Edward E. Pochin
    Pages 1-16

  3. The effect on industry

    • B. B. Newbould
    Pages 17-25

  4. The effect on the public

    • J. Maddox, J. Coombes
    Pages 27-42

  5. The necessary role of government

    • D. Ennals
    Pages 43-49

  6. Problems facing a regulatory authority

    • D. G. Grahame-Smith, J. Coombes
    Pages 51-66

  7. The effect on pharmaceutical research

    • C. N. Christensen
    Pages 67-73

  8. New-drug assessment in man: a clinical pharmacologist’s view

    • A. M. Breckenridge, T. I. Wrigley
    Pages 75-92

  9. The effect on choice of research

    • P. A. J. Janssen
    Pages 93-95

  10. The relative worth of animal testing

    • A. D. Dayan
    Pages 97-112

  11. The prospect of product liability

    • J. D. Spink, T. I. Wrigley
    Pages 113-130

  12. The effect on world medicine

    • J. F. Dunne
    Pages 131-134

  13. Preclinical requirements

    • R. W. Brimblecombe
    Pages 135-140

  14. Post-marketing drug surveillance

    • W. H. W. Inman, C. T. Dollery
    Pages 141-161

  15. The influence of the media

    • S. Lock, C. T. Dollery
    Pages 163-177

  16. The influence of the medical profession

    • Douglas Black
    Pages 179-184

  17. Summary and Conclusions

    • C. T. Dollery
    Pages 185-190

  18. Back Matter

    Pages 191-197
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Keywords

About this book

The appreciation of risk like the awareness of beauty lies very much in the eyes of the beholder. It involves a value judgement and can never be absolute. Yet paradoxically, modern society is demanding ever greater degrees of safety in the medicines it takes, to the extent that nothing short of the total absence of risk will be tolerated. Since 1960, and mainly as a result of the thalidomide tragedy, governmental regulation of testing and use of new medicines has grown apace throughout the world. It has derived impetus not only from the understandable wish of the public to seek protection, but also from the anxiety of bureaucrats and politicians not to be seen to have made mistakes. Both these concerns have been inflamed by the recognition of the media that all drugs make news and horror drugs make the best news of all. Prior to this time the physician and his cures enjoyed a relatively supportive public. It was true that quacks existed and were recognized as such but, in the main, people wanted to take medicines and expected them to do them good.

Editors and Affiliations

  • Wyeth Laboratories, Taplow, Maidenhead, Berkshire, England

    J. F. Cavalla

Bibliographic Information

  • Book Title: Risk-Benefit Analysis in Drug Research

  • Book Subtitle: Proceedings of an International Symposium held at the University of Kent at Canterbury, England, 27 March 1980

  • Editors: J. F. Cavalla

  • DOI: https://doi.org/10.1007/978-94-015-7132-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: MTP Press Limited 1981

  • Softcover ISBN: 978-94-015-7134-0Published: 04 August 2012

  • eBook ISBN: 978-94-015-7132-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 197

  • Number of Illustrations: 7 b/w illustrations

  • Topics: Pharmacology/Toxicology

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