Cell death in biology and pathology

1. Front Matter

   Pages i-xviii

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2. Introduction

   • I. D. Bowen, R. A. Lockshin

   Pages 1-7

3. Cell death: a new classification separating apoptosis from necrosis

   • A. H. Wyllie

   Pages 9-34

4. Cell death in embryogenesis

   • J. R. Hinchliffe

   Pages 35-78

5. Cell death in metamorphosis

   • Richard A. Lockshin

   Pages 79-121

6. Tissue homeostasis and cell death

   • S. M. Hinsull, D. Bellamy

   Pages 123-144

7. Cell senescence and death in plants

   • P. B. Gahan

   Pages 145-169

8. The tissue kinetics of cell loss

   • N. A. Wright

   Pages 171-207

9. Cell death and the disease process. The role of calcium

   • Benjamin F. Trump, Irene K. Berezesky, Alvaro R. Osornio-Vargas

   Pages 209-242

10. Cell death in vitro

    • Leonard Hayflick

    Pages 243-285

11. Nucleic acids in cell death

    • Richard A. Lockshin, Moira Royston, Michael Joesten, Timothy Carter

    Pages 287-293

12. Mechanism(s) of action of nerve growth factor in intact and lethally injured sympathetic nerve cell in neonatal rodents

    • Rita Levi-Montalcini, Luigi Aloe

    Pages 295-327

13. Glucocorticoid-induced lymphocyte death

    • Allan Munck, Gerald R. Crabtree

    Pages 329-359

14. The role of the LT system in cell destruction in vitro

    • Monica W. Ross, Robert S. Yamamoto, Gale A. Granger

    Pages 361-377

15. Techniques for demonstrating cell death

    • I. D. Bowen

    Pages 379-444

16. Back Matter

    Pages 445-493

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It is clear that lysosomal enzymes often play a role in the destruction of the cytoplasm, but very few authorities feel that they initiate the process (Chapters 1, 2, 3, 5 -8, 12, 13). The cells show many forms of damage, and sometimes even complete destruction, before Iysosomes become a dominant part of the environ­ ment. What initiates the process is still unclear, although in several instances it appears that the death of a cell may arise from anyone of several pathways (Chapters, 10, II). It is rather interesting that evolution has chosen to achieve the same goal by different means. Apparently no one point is exceptionally or pre­ ferentially vulnerable, though a common pathway, such as permeability of the plasma membrane to calcium (Chapter 7), might currently be too subtle for routine identification. Factors which affect membrane stability and which induce mem­ brane bending can lead to blebing, cell fragmentation and death. Thus, more work on the changing chemistry of the plasma membrane in relation to environmental fluctuations would be welcomed. Space requirements and the major orientation of the book forced the exclusion of several very interesting topics: an evolutionary treatment of the advantages of cell death as a means of eliminating vestigial organs or embryonic scaffolding; or consider­ ation of the merits of body sculpting by cell death rather than cell growth.

• DNA
• DNA repair
• biology
• cell
• cell cycle
• cell death
• enzyme
• evolution
• growth
• insects
• membrane
• morphology
• programmed cell death
• proteins
• tissue

• Department of Zoology, University College, Cardiff, UK

  I. D. Bowen

• Department of Biological Sciences, St John’s University, New York, USA

  R. A. Lockshin

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