Pathogenesis and Treatment of Diabetes Mellitus

1. Front Matter

   Pages I-XII

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2. Pathogenesis of Diabetes Mellitus

   1. Type I Diabetes Mellitus

      1. Introduction: Type I Diabetes Mellitus

         • J. K. Radder

         Pages 1-10

      2. Autoimmune pathogenesis of viral diabetes

         • P. G. Babu, S. A. Huber, J. E. Graighead

         Pages 11-15

      3. Immunological features of insulin-dependent diabetes mellitus

         • F. Beeker, G. F. Bottazzo

         Pages 16-26

      4. Genetic counselling in Diabetes Mellitus

         • R. B. Tattersall

         Pages 27-32

   2. Type II Diabetes Mellitus

      1. Introduction: Pathogenesis of type II Diabetes Mellitus

         • H. M. J. Krans

         Pages 33-38

      2. Insulin secretion in noninsulin-dependent Diabetes Mellitus

         • V. Broadstone, W. K. Ward, J. G. Beard, J. D. Best, J. B. Halter, R. Judzewitsch et al.

         Pages 39-57

      3. Insulin antagonism

         • P. J. Lefebvre, A. S. Luyckx

         Pages 58-62

      4. The contribution of the central nervous system to the regulation of insulin release and the stabilization of blood glucose

         • A. B. Steffens, P. G. M. Luiten

         Pages 63-74

      5. Cellular insulin resistance

         • Tj. Wieringa

         Pages 75-82

3. Treatment of Diabetes Mellitus

   1. Diet and hypoglycaemic agents

      1. Introduction: Diet and hypoglycaemic agents

         • J. L. Touber

         Pages 83-90

      2. Diet and Diabetes

         • R. G. Josse, A. L. Jenkins, D. J. A. Jenkins

         Pages 91-102

      3. Oral hypoglycaemic drugs

         • H. Keen, S. Ng Tang Fui

         Pages 103-120

   2. Insulin

      1. Introduction: Insulin treatment

         • J. Terpstra

         Pages 121-122

      2. Hyperinsulinaemia

         • E. R. Trimble

         Pages 123-130

      3. Insulin: The physiological basis of its administration

         • D. R. Matthews

         Pages 131-141

      4. Diabetes Technology: From the pump to the microprocessor

         • A. M. Albisser, B. S. Leibel

         Pages 142-151

   3. Pancreas transplantation

      1. Introduction: Pancreas transplantation

         • H. H. P. J. Lemkes

         Pages 152-155

      2. Current state of pancreas transplantation

         • P. McMaster, W. A. Jurewics, B. H. Gunson, R. M. Kirby

         Pages 156-165

4. Back Matter

   Pages 167-172

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In this book on diabetes mellitus both the pathogenesis and treat­ ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol­ ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre­ disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto­ immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out­ break of the disease, the destructive process has already been active for years.

• Diabetes
• Diabetes mellitus
• Insulin
• Pancreas
• Viral Diabetes

• Department of Endocrinology and Metabolism, Leiden University Hospital, Leiden, The Netherlands

  J. K. Radder, H. H. P. J. Lemkes, H. M. J. Krans

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