The Role of Oxygen Radicals in Cardiovascular Diseases

1. Front Matter

   Pages i-x

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2. Oxygen Toxicity: Biochemical, Physiological and Pathological Aspects

   • Lars Ernster

   Pages 1-2

3. Morphologic Differences in Myocardial Necrosis and Atherosclerotic Plaque. What is their Pathogenetic Meaning?

   • G. Baroldi

   Pages 3-12

4. Free Radicals and Circulatory Shock

   • Gian Paolo Novelli

   Pages 13-22

5. Reperfusion Arrhythmias: Do Free Radicals Play a Role?

   • David J. Hearse

   Pages 23-34

6. Diene Conjugation in the Clinical Measurement of Free-Radical Activity

   • T. L. Dormandy, D. G. Wickens

   Pages 35-50

7. Conversion of Rat Xanthine Dehydrogenase to Xanthine Oxidase during Oxidative Stress

   • A. Bindoli, L. Cavallini, M. P. Rigobello, M. Coassin, F. Di Lisa

   Pages 51-69

8. Cardiac Cell Breakdown at Reoxygenation: Absence of Changes in Xanthine Oxidase and Effects of Calcium Concentration

   • James P. Kehrer

   Pages 71-89

9. Oxidative Stress in the Myocardium: Relationship with Eicosanoid Biosynthesis and Tissue Damage

   • Fulvio Ursini, Gualtiero Pelosi, Antonio Benassi, Renata Barsacchi

   Pages 91-104

10. The Reaction between Oxymyoglobin and Hydroperoxides

    • Diego Mira, Ulf Brunk, Fulvio Ursini, Enrique Cadenas

    Pages 105-116

11. The Role of Iron Mobilization in Ischemic Tissue Damage

    • J. F. Koster, H. Stam, P. Biemond

    Pages 117-125

12. Role of Lipid Peroxidation in Increasing Calcium Permeability of Model and Natural Membranes

    • D. O. Levitsky, A. V. Lebedev, A. V. Kuzmin, V. M. Brovkovich

    Pages 127-141

13. Cytotoxic Mechansims for Cholesterol Oxidation Products in Fibroblasts and Endothelial Cells

    • Alex Sevanian

    Pages 143-168

14. Possible Importance of Proteolytic Systems as Secondary Antioxidant Defenses During Ischemia-Reperfusion Injury

    • Kelvin J. A. Davies, Yin Zhang, Olivier Marcillat

    Pages 169-185

15. Inhibition by Some Synthetic Antioxidants of the Agonist-Induced Activation of Aspirinated Platelets and of the Depolarization-Induced Release of Neurotransmitter from Brain Synaptosomes

    • Adolfo Alexandre, M. Gabriella Doni, Franco Zoccarato, Renzo Deana

    Pages 187-199

16. Pulmonary Vascular Injury from Reactive Oxygen Species

    • Bruce A. Freeman, Peter Panus, Joseph S. Beckman, Sadis Matalon

    Pages 201-215

17. Changes of Activity of Intracellular Antioxidant Enzymes of Heart in Response to Ischemia-Reperfusion

    • G. Rotilio, C. Guarnieri, I. Mavelli

    Pages 217-230

18. Enzymatic Defense Systems Against Hydroperoxides and Oxygen-Centered Radicals in Mammals: Glutathione Peroxidase and Superoxide Dismutases

    • L. Flohé, W. Straßburger, W. A. Günzler

    Pages 231-243

19. Antioxidant Mechanisms in the Heart: The Potential Involvement of Myoglobin

    • Paul Hochstein

    Pages 245-252

20. The Cardiac Defense System Associated with Glutathione

    • Toshihisa Ishikawa

    Pages 253-269

Growing experimental evidence is beeing produced in support of the thesis that lipid pe,oxidation is an important mediator of both vascular and myocardial tissue derangement. Although the role of the free-radical system in human cardiovascular pathology remains speculative, nevertheless the potential implications of such a system in both pharmacological therapy and prevention of major cardiovascular diseases, such as myocardial infarction, cardiomyopathy and arrhythmias, justify the increasing interest of clinical cardiologists in this research area. Furthermore, present-day clinical cardiology permits to reproduce in man such experimental models as ischemia and reperfusion, e.g. during percutaneous transluminal angioplasty, and even to gain histological and histochemical access to byoptic myocardial tissue. Upon above premises the idea of a multidisciplinary discussion meeting was conceived, aimed to confront clinical expectations with acquired basic information, and to discuss the validity of experimental models in the light of pathological and clinical findings in man. To this purpose, a unique group of experts in the field of free-radicals, from all over the world, was asked to make the topic accessible to clinical cardiologists, with the primary aim of projecting results and ideas towards potential clinical research; this is, in fact, the object of the European Concerted Action "Breakdown in Human Adaptation - Cardiovascular Diseases", in the frame of which the meeting was held.

• arrhythmia
• atherosclerosis
• cardiology
• cardiovascular
• heart
• heart disease
• myocardial infarction
• platelet
• vascular disease

• Institute of Clinical Physiology, CNR, Pisa, Italy

  A. L’Abbate

• Institute of Biochemistry, Padova, Italy

  F. Ursini

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