Vasopressin

1. Front Matter

   Pages I-XIV

   PDF

2. Basal Mechanisms of Water and Salt Homeostasis

   • L. Kovács, B. Lichardus

   Pages 1-12

3. Hypothalamo-Neurohypophyseal Hormones and Neurophysins

   • L. Kovács, B. Lichardus

   Pages 13-18

4. Neurosecretion

   • L. Kovács, B. Lichardus

   Pages 19-29

5. Biosynthesis, Transport and Release of Vasopressin

   • L. Kovács, B. Lichardus

   Pages 30-37

6. Regulation of Vasopressin Secretion and Thirst

   • L. Kovács, B. Lichardus

   Pages 38-62

7. Vasopressin Assays

   • L. Kovács, B. Lichardus

   Pages 63-66

8. Receptors and Synthetic Analogs of Vasopressin

   • L. Kovács, B. Lichardus

   Pages 67-78

9. Vasopressin and Renal Regulation of Water Homeostasis

   • L. Kovács, B. Lichardus

   Pages 79-105

10. Vasopressin in Circulatory Control

    • L. Kovács, B. Lichardus

    Pages 106-113

11. Vasopressin and Hemostasis

    • L. Kovács, B. Lichardus

    Pages 114-119

12. Vasopressin and Anterior Pituitary Function

    • L. Kovács, B. Lichardus

    Pages 120-122

13. Vasopressin and Brain Function

    • L. Kovács, B. Lichardus

    Pages 123-129

14. Metabolic Effects of Vasopressin

    • L. Kovács, B. Lichardus

    Pages 130-130

15. Clinical Disturbances of Vasopressin Secretion and Effects (Hypo- and Hypervasopressinism)

    • L. Kovács, B. Lichardus

    Pages 131-135

16. Ontogenesis of Body Water Homeostasis and Vasopressin Secretion

    • L. Kovács, B. Lichardus

    Pages 136-157

17. Renal Water Handling, Vasopressin Secretion and Thirst Sensation in the Elderly

    • L. Kovács, B. Lichardus

    Pages 158-160

18. Clinical Syndromes Associated with Hypovasopressinism

    • L. Kovács, B. Lichardus

    Pages 161-202

19. Hypertonic Syndromes

    • L. Kovács, B. Lichardus

    Pages 203-211

20. Hypervasopressinism

    • L. Kovács, B. Lichardus

    Pages 212-214

The mechanisms by which animals regulate the volume and composition of their body fluids has long had a particular fascination for students of biology. As a consequence, the subject can lay claim to an impressive record of ground­ breaking scientific achievements as well as a provocative body of philosophical speculation concerning the role of the system in the origin and evolution of life. Indeed, the entire concept of homeostasis on which so much of o~r current biologic thinking is based, derives from Claude Bernard's pioneering exploration of the forces that determine the composition of this 'internal sea'. Other seminal achievements credited to this area of inquiry include the first description of a genetically transmitted human disease (familial neurogenic diabetes insipidus); the first isolation sequencing and synthesis of a peptide hormone (vasopressin and oxytocin); the first demonstration of peptide hormone synthesis by way of a larger protein precursor; the first description of resistance to the biologic actions of a hormone (nephrogenic diabetes insipidus); and the conceptual realization of the unique counter-current mechanism that permits concentration of the urine. This record of far reaching and fundamental advances has been distinguished by many fruitful inter­ actions between clinical and basic science.

• Atmen
• Diabetes
• childhood
• homeostasis
• pregnancy

• Department of Pediatrics, Comenius University Medical School, Bratislava, Czechoslovakia

  L. Kovács

• Institute of Experimental Endocrinology, Center of Physiological Sciences of the Slovak Academy of Sciences, Bratislava, Czechoslovakia

  B. Lichardus

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