New Trends in Hepatology

1. Front Matter

   Pages i-x

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2. Pathogenetic Mechanisms of Liver Injury

   1. Front Matter

      Pages 1-1

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   2. 4-Hydroxy-Alkenals, Products of Lipid Peroxidation, as Signals for Biochemical Functions of Normal Cells

      • M. U. Dianzani

      Pages 3-16

   3. Oxidative Stress and Protein Kinase C Activity Modulation

      • C. Domenicotti, G. Santori, M. A. Pronzato, D. Cottalasso, R. Ricciarelli, A. Lamedica et al.

      Pages 17-23

   4. Oxidative Damage in Chronic and Acute Liver Disease.

      • Elisabetta Baldi, Patrizia Burra, Romilda Cardin, Maria Chiaramonte, Stefano Fagiuoli, Fabio Farinati et al.

      Pages 24-32

   5. Chronic Ethanol Consumption Impairs Dolichol Levels and Glycosylation Processes in Rat Liver Microsomes and Golgi Apparatus

      • D. Cottalasso, C. Domenicotti, M. A. Pronzato, N. Traverso, A. Bellocchio, D. Dapino et al.

      Pages 33-41

   6. Compartmentation and Redox State of Thiols and Proteins During Acute Ethanol Intoxication in Rats

      • E. Altomare, G. Vendemiale, I. Grattagliano, A. Signorile, A. Pistone, M. Cassano et al.

      Pages 42-47

   7. Possible Role of Ethanol-Derived Free Radicals in the Pathogenesis of Alcohol-Induced Liver Damage

      • E. Albano, P. Clot, M. Parola, M. U. Dianzani

      Pages 48-55

   8. Hepatic Iron Overload Induced by Phenylhydrazine: Release of Iron in a Free Form and DNA Damage

      • M. Comporti, C. Signorini, L. Sugherini, A. Pompella, L. Ciccoli, M. Ferrali

      Pages 56-64

   9. The Effects of Development of the MDR1 Phenotype on Cell Susceptibility to Undergoing Lipid Peroxidation and Ionizing Radiation.

      • Roberto Mazzanti, Ornella Fantappiè, Paola Fabrizio

      Pages 65-73

   10. Molecular and Cellular Aspects of Iron-Mediated Liver Toxicity

       • Antonello Pietrangelo, Giuliana Montosi, Rossana Gualdi, Cinzia Garuti, Ezio Ventura

       Pages 74-84

   11. The Cellular and Molecular Basis of Liver Fibrogenesis

       • Massimo Pinzani, Fabio Marra, Vinicio Carloni, Alessandra Caligiuri, Raffaella De Franco, Alessandra Gentilini et al.

       Pages 85-92

   12. Proliferation of Hepatic Stellate Cells and Lipid Peroxidation: Changes Due to Polyphenols.

       • G. Svegliati Baroni, L. D’ Ambrosio, G. Ferretti, P. Biondi, A. Casini, A. Di Sario et al.

       Pages 93-103

   13. Reoxygenation Injury in Isolated Rat Hepatocytes

       • Paolo Caraceni, Antonio Gasbarrini, Franco Trevisani, Marco Domenicali, Giovanni Gasbarrini, David H. Van Thiel et al.

       Pages 104-112

   14. Oxidative Stress and Cell Damage Following Orthotopic Liver Transplantation.

       • E. Chiarpotto, F. Biasi, J. Cutrin, M. Salizzoni, G. Lanfranco, M. Rizzetto et al.

       Pages 113-121

   15. The Genomic Response of Liver Cells to Post-Ischemic Reperfusion and Oxidative Stress.

       • A. Bernelli-Zazzera

       Pages 122-129

3. Pathophysiology of Bile Secretion

   1. Front Matter

      Pages 131-131

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   2. Cytotoxic and Protective Effects of Bile Salts in Vitro

      • Francesca Carubbi, M. Eugenia Guicciardi, Mauro Concari, Mara Bozzoli, Nicola Carulli

      Pages 133-141

   3. Lamellar Bodies in Human Gallbladder Bile

      • S. Ginanni Corradini, M. Angelico, P. Della Guardia, L. Baiocchi, C. Ripani, L. Giovannelli et al.

      Pages 142-148

   4. Hepatocyte Lipid-Metabolic Interplays and the Cholesterol Secretion Process to Bile: Insights from Rat Studies.

      • Massimino Carrella

      Pages 149-157

The Italian Group for the Study of Liver Cirrhosis began its activity in 1980 on the basis of recognition and financial support from the Italian Ministry of the University, Scientific Research and Technology, having been chosen from several other scientific programs. The group is now called the National Group for the Study of Liver Cirrhosis and Viral Hepatitis and includes more than 40 centers throughout the nation under the auspices of the universities. The primary Imtlatlve of the group, to combine experimental and clinical approaches in the study of liver pathophysiology, remains unchanged. Annual meetings in January provide the possibility of comparing experimental and clinical results in the spirit of mutual comprehension and criticism. After 15 years and 6 volumes (published biannually), the actual improvement of Italian research in liver pathophysiology is evident. In fact, in order to let other researchers know what has been achieved we chose to publish the 7th volume, in spite of the economic difficulties at hand. We have gathered specific experiences of all the centers included in the national program. Each group was required to present an update in its own field of research, rather than specific or recently obtained results, which could have been reported only in relationship with other data already published by others. Like the 6th edition in our series, this volume affirms the specific competence of all the participants and summarizes the most important updates in liver pathophysiology.

• cancer
• hepatitis
• hepatology
• liver
• liver disease
• liver transplantation
• transplantation
• viral hepatitis

• Institute of Internal Medicine, School of Medicine, University of Florence, Florence, Italy

  Paolo Gentilini

• Department of Experimental Medicine and Oncology, Section of General Pathology, University of Turin, Turin, Italy

  Mario Umberto Dianzani

Policies and ethics