Animal Cell Technology

1. Front Matter

   Pages i-xviii

   PDF

2. Keynote Lectures

   1. Front Matter

      Pages 1-1

      PDF

   2. Molecular Biology of Prion Diseases

      • C. Weissmann

      Pages 3-6

   3. Applications of Animal Cell Technology to Drug Discovery and Pharmacology

      • W.-D. Schleuning

      Pages 7-14

   4. Biogenesis of Secretory Proteins and Cell Surface Receptors in Mammalian Cells: Posttranslational Modifications and Protein Folding within the Rough Endoplasmic Reticulum

      • Harvey F. Lodish

      Pages 15-26

3. Cells and Vectors for Genetic Medicine

   1. Front Matter

      Pages 27-27

      PDF

   2. Polymer Encapsulated Xenogeneic Cell Lines: A Novel Approach for Gene Therapy

      • P. Aebischer

      Pages 29-31

   3. Gene Therapy and Genetic Vaccination: Two Hallmarks of Genetic Medicine

      • Dalemans Wilfried

      Pages 33-35

   4. PCR Detection of Murine Retroviruses and Characterization of a New Xenotropic Retrovirus from Myeloma Cells

      • Manfred Wirth, Thomas Heinemeyer, Lorin Schumacher, Andreas Klingenhoff, Wiebke Hansen, Zoltan Suemeghy et al.

      Pages 37-42

   5. Toward a DNA Vaccine Against Lyssa Viruses

      • C. Bahloul, F. Fouque, N. Tordo, Y. Jacob, P. Perrin

      Pages 43-46

   6. Principles of a Scaleable Transient Transfection and Expression Technology for Mammalian Cells

      • Martin Jordan, Christiane KÖhne, Florian M. Wurm

      Pages 47-50

   7. Neurological Therapy — Adenovirus Mediated Gene Therapy in Cells of the Central Nervous System

      • S. D. Sivasubramaniam, A. R. Fooks, J. Lee, G. Stacey, A. D. Jennings

      Pages 51-56

   8. Bovine Polyoma Virus Detection by Routine PCR Screening

      • Joanne Proffitt, Keri Jarvis, Carl Martin

      Pages 57-62

4. Animal Cells as Tools for Discovery and Testing

   1. Front Matter

      Pages 63-63

      PDF

   2. Mammalian Cells in High Throughput Screening

      • William Janzen

      Pages 65-71

   3. Metabolism and Toxicological Studies in Immortalised Rat Hepatocyte Cell Lines

      • C. MacDonald, F. Reid, K. Anderson, L. Yin, E. Hill, H. Kelly et al.

      Pages 73-78

   4. Cell Based Assays for Drug Screening

      • Elizabeth Keenan, Helen Kruger, Balwinder Sambi, John S. McLean

      Pages 79-84

   5. Development of Drug Metabolism Simulator Using Three-Dimensional Culture of Hepatocytes of Rats and Dogs

      • Kazumori Funatsu, Kohji Nakazawa, Hiroshi Mizumoto, Kenji Takenaka, Taku Matsushita

      Pages 85-90

   6. Immobilization of Primary Brain Cells in Porous Microcarriers for on Line NMR Spectroscopy

      • P. M. Alves, M. J. T. Carrondo, H. Santos

      Pages 91-98

   7. Application of primary hepatocyte sandwich cultures for predictive studies of drug metabolism and precarcinogen activation

      • A. Bader, R. Fahrig, A. Steinkamp, N. Frühauf, O. Crome, K. Zech et al.

      Pages 99-102

Animal cell technology has undergone a rapid transformation over the last decade from a research tool and highly specialised technology to a central resource for innovation in pharmaceutical research and development. These proceedings of the 14th Meeting of the European Society for Animal Cell Technology (Vilamoura, Portugal, May 1996) bring up to date the historical perspective of animal cell technology for the benefit of society, `From Vaccines to Genetic Medicine', and will charter this vital technology for the years to come.
Strong contributions are grouped in the traditional ESACT areas of 'Cell and Physiology Engineering' dealing with cell state, including genetics, and its environment, and 'Animal Cell Process Engineering' covering integration of bioreaction with bioseparation coupled with on-line monitoring to improve protein production and consistency. Extensive coverage of metabolic engineering on synthesis, folding, assembly, transiting and secretion is dealt with in the session on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. Two traditional but expanding areas of animal cell technology relevance are highlighted in the broad sessions of 'Animal Cells as Tools for Discovery and Testing' and 'Animal Cell Vaccines: Present and Future'. Two sessions finally cover the more recent domains of animal cell technology work - 'Tissue Engineering and Biomedical Devices' and 'Cells and Vectors for Genetic Medicine' - where one can foresee a very bright future.

• Tissue Engineering
• development
• physiology
• process engineering
• protein
• reaction
• tissue

• IBET, Oeiras, Portugal

  Manuel J. T. Carrondo, José L. P. Moreira

• CAMR, Porton Down, Wiltshire, UK

  Bryan Griffiths

Policies and ethics