The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

1. Front Matter

   Pages i-xv

   PDF

2. Introduction to the field

   1. Introduction to the field

      • W. H. Fridman

      Pages 1-7

3. Physiological Role of Fc Receptors

   1. Front Matter

      Pages 9-9

      PDF

   2. General aspects of FcR

      1. Molecular basis for the interaction of Fc receptors with immunoglobulins

         • A. Gavin, M. Hulett, P. M. Hogarth

         Pages 11-35

      2. Fc receptor genetics and the manipulation of genes in the study of FcR biology

         • T. Takai, J. V. Ravetch

         Pages 37-48

      3. Commentary

         • R. G. Lynch

         Pages 49-50

   3. FcR and Ig-transport/catabolism

      1. The polymeric immunoglobulin receptor

         • C. Kaetzel, K. Mostov

         Pages 51-62

      2. Multiple roles of FcRn

         • N. E. Simister

         Pages 63-71

      3. <i>Commentary</i> The polymeric immunoglobulin receptor and the Brambell receptor: non-haematopoietic FcRs, with much to compare

         • R. P. Junghans

         Pages 73-82

   4. FcR and cell activation

      1. Signals initiated by the high affinity FcR for IgE

         • O. H. Choi, P. G. Holbrook

         Pages 83-93

      2. Phagocyte Fc receptors for IgG

         • S. E. Mckenzie, Z. K. Indik, A. D. Schreiber

         Pages 95-107

      3. Human IgA Fc receptors (FcαR)

         • H. C. Morton, M. van Egmond, J. G. J. van de Winkel

         Pages 109-117

      4. Platelet Fc receptors for IgG and IgE

         • A. Greinacher

         Pages 119-134

      5. Polymorphisms of FcγRIIIa on NK cells and macrophages

         • H. R. Koene, A. E. G. Kr. Von Dem Borne, D. Roos, M. de Haas

         Pages 135-140

      6. Cooperation between IgG Fc receptors and complement receptors in host defence

         • E. J. Brown

         Pages 141-149

      7. Commentary

         • H. Metzger

         Pages 151-154

   5. FcR and immunoregulation

      1. FcγR and IgG-mediated negative regulation of immune responses

         • M. Daëron, B. Heyman

         Pages 155-167

      2. FcγR on T cells

         • M. Sandor, R. G. Lynch

         Pages 169-183

      3. Role of IgG and IgE FcR in antigen presentation

         • P. M. Guyre, J. K. O’Shea

         Pages 185-194

      4. Structure and function of CD23

         • D. H. Conrad

         Pages 195-206

Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.

• Antigen
• autoimmunity
• infectious
• infectious disease
• infectious diseases
• physiology

• Utrecht University, Utrecht, The Netherlands

  Jan G. J. Winkel

• Austin Research Institute, Melbourne, Australia

  P. Mark Hogarth

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