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Molecular Basis of Neurological Disorders and Their Treatment

  • Book
  • © 1991

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Editors:
  1. J. W. Gorrod

    1. Chelsea Department of Pharmacy, King’s College London, University of London, London, UK

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  2. O. Albano
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  3. E. Ferrari
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  4. S. Papa

    1. Institute of Medical Biochemistry and Chemistry and Centre for the Study of Mitochondria and Energy Metabolism, University of Bari, Italy

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xv
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  2. Biochemical Function, Probes and Imaging

    1. Front Matter

      Pages 1-1
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    2. Towards a molecular model of the acetylcholine receptor channel

      • A. Pullman
      Pages 3-14

    3. Proton-motive ATP synthase and energy transfer in the cell

      • S. Papa, F. Guerrieri, F. Zanotti
      Pages 15-30

    4. Comparative analysis of the amount of subunit I and subunit IV of cytochrome c oxidase mRNAs in the cerebral hemispheres of senescent rat and effect of acetyl-L-carnitine

      • M. N. Gadaleta, V. Petruzzella, M. Renis, F. Fracasso, P. Cantatore
      Pages 31-39

    5. Cytochemical and immunocytochemical investigation of respiratory complexes in individual fibres of human skeletal muscle

      • M. A. Johnson
      Pages 40-56

    6. Native myelin proteins and myelin assembly in the central nervous system

      • P. Riccio, A. Bobba, G. M. Liuzzi, T. Zacheo, E. Quagliariello
      Pages 57-64

    7. Regulation of immune cells by serine phospholipids

      • A. Bruni, L. Mietto, F. Bellini, D. Ponzin, E. Caselli, G. Toffano
      Pages 65-72

    8. Cell adhesion molecules belonging to the immunoglobulin superfamily

      • G. Gennarini, F. Vitiello, P. Corsi, G. Cibelli, M. Buttiglione, C. Di Benedetta
      Pages 73-79

    9. Neurogenic control of cerebral blood vessels

      • C. Alafaci, F. M. Salpietro, F. Tomasello
      Pages 80-92

    10. The fine structural aspects of brain oedema and associated microvascular and glial changes

      • A. Hirano, R. Waki
      Pages 93-99

    11. Image-guided localized nuclear magnetic resonance spectroscopy of human brain tumours

      • W. Heindel, W. Steinbrich, J. Bunke, G. Friedmann
      Pages 100-106

    12. Neuroimaging study of frontal lobes

      • G. L. Lenzi, A. Padovani, P. Pantano, M. Iacoboni, M. Ricci, P. Franco et al.
      Pages 107-111

  3. Neuropathies, Myopathies and other Dysfunctions

    1. Front Matter

      Pages 113-113
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    2. Biochemical indicators of ischaemic brain damage

      • H. Somer, R. O. Roine
      Pages 115-128

    3. Molecular basis of astroglial reaction to brain injury: regulation of glial fibrillary acidic protein mRNA in rat cerebral cortex and in primary astroglial cell cultures

      • D. F. Condorelli, A. M. Giuffrida Stella
      Pages 129-138

    4. Tissue plasminogen activator: acute thrombotic stroke

      • Gregory J. Del Zoppo
      Pages 139-153

    5. Lysosomal storage of a mitochondrial protein in Batten’s disease (ceroid lipofuscinosis)

      • S. M. Medd, J. E. Walker, I. M. Fearnley, R. D. Jolly, D. N. Palmer
      Pages 154-165

    6. Leber’s hereditary optic neuropathy: from the clinical to the neurobiochemical and molecular findings for understanding the pathogenesis of the disorder

      • A. Federico
      Pages 166-172

    7. Types and mechanism of mitochondrial DNA mutations in mitochondrial myopathy and related diseases

      • T. Ozawa, M. Tanaka, W. Sato, K. Ohno, M. Yoneda, T. Yamamoto
      Pages 173-190
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Keywords

About this book

cytochemical techniques (ICC) which provide a useful adjunct to investigations by immunoblotting. A particular advantage of a cytochemical approach to the investiga­ tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza­ tion involved in conventional enzyme assays or immunoblotting precludes this. A further advantage of MEA or ICC is that only small amounts of tissue are needed, which is important since many of the affected patients are infants or small children. The main aim of this communica­ tion is to outline ways in which these techniques can be used in the diagnosis and further investigation of mitochondrial disorders. Reference will be made not only to those situations in which MEA and ICC offer advantages over standard enzyme asays and immunoblotting but also to contexts in which the reverse applies. 4. 2 MATERIALS AND METHODS Muscle biopsies for cytochemical investigation were snap-frozen using isopentane cooled to - 150°C in liquid nitrogen. Samples were stored in heat-sealed polythene packets in the vapour phase of liquid nitrogen containers. 4. 2. 1 Microphotometric enzyme assays Frozen sections 8 Jlm thick were cut using a Reichert-J ung Frigocut cryostat microtome equipped with motor-driven cutting action to maintain maximal reproducibility of section thickness. Sections were picked up on microscope slides and air-dried for 15 min at room temperature.

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Editors and Affiliations

  • Chelsea Department of Pharmacy, King’s College London, University of London, London, UK

    J. W. Gorrod

  • Institute of Medical Biochemistry and Chemistry and Centre for the Study of Mitochondria and Energy Metabolism, University of Bari, Italy

    S. Papa

Bibliographic Information

  • Book Title: Molecular Basis of Neurological Disorders and Their Treatment

  • Editors: J. W. Gorrod, O. Albano, E. Ferrari, S. Papa

  • DOI: https://doi.org/10.1007/978-94-011-3114-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1991

  • Hardcover ISBN: 978-0-412-40410-8Published: 30 June 1991

  • Softcover ISBN: 978-94-010-5379-2Published: 08 October 2012

  • eBook ISBN: 978-94-011-3114-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XV, 337

  • Topics: Neurosciences, Animal Anatomy / Morphology / Histology, Neurology

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