Editors:

P. Hlavica (Full Professor of Pharmacology and Toxicology)⁰,
L. A. Damani (Lecturer in Biopharmacy)¹

P. Hlavica
1. Ludwig-Maximilians-Universität München, Munich, Germany
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L. A. Damani
1. Chelsea Department of Pharmacy, King’s College, University of London, UK
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Table of contents (26 chapters)

Front Matter

Pages i-xx

PDF
Analysis of N-Oxidized Products
1. Front Matter
  
  Pages 1-1
  
  PDF
2. Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products
  
  T. E. Eling, J. F. Curtis, D. C. Thompson, J. Van der Zee, R. P. Mason
  
  Pages 3-18
3. The Application of ¹⁵N-NMR in the Analysis of N-Oxygenated amidines and guanidines
  
  B. Clement, Th. Kämpchen
  
  Pages 19-35
4. Radioimmunoassay and other methods for trace analysis of N-oxide compounds
  
  K. K. Midha, T. J. Jaworski, E. M. Hawes, G. McKay, J. W. Hubbard, M. Aravagiri et al.
  
  Pages 37-55
Enzymology of N-Oxidation
1. Front Matter
  
  Pages 57-57
  
  PDF
2. Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenases
  
  D. M. Ziegler
  
  Pages 59-70
3. On the genetic polymorphism of the flavin-containing mono-oxygenase
  
  P. Hlavica, I. Golly
  
  Pages 71-90
4. Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenase
  
  D. E. Williams
  
  Pages 91-105
5. Human pharmacogenetics of nitrogen oxidations
  
  S. Cholerton, R. L. Smith
  
  Pages 107-131
6. Microbial N-hydroxylases
  
  H. Diekmann, H. J. Plattner
  
  Pages 133-139
7. Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylamines, and N,N-dimethylanilines by cytochrome P-450 enzymes
  
  F. P. Guengerich, A. Bondon, R. G. Böcker, T. L. Macdonald
  
  Pages 141-155
8. The role of cytochrome P-450 in the biological nuclear N-oxidation of aminoaza-heterocyclic drugs and related compounds
  
  J. W. Gorrod, S. P. Lam
  
  Pages 157-184
9. New aspects of the microsomal N-hydroxylation of benzamidines
  
  B. Clement, M. Immel, H. Pfundner, S. Schmitt, M. Zimmermann
  
  Pages 185-205
10. Studies on the N-oxidation of phentermine: evidence for an indirect pathway of N-oxidation mediated by cytochrome P-450
  
  A. K. Cho, J. D. Duncan, J. M. Fukuto
  
  Pages 207-215
11. Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase products
  
  P. J. O’Brien, S. Jatoe, L. G. McGirr, S. Khan
  
  Pages 217-236
Reductions and Conjugations of N-Oxygenated Compounds
1. Front Matter
  
  Pages 237-237
  
  PDF
2. Reduction and conjugation reactions of N-oxides
  
  L. A. Damani
  
  Pages 239-261
3. In vivo metabolism of N-oxides
  
  E. M. Hawes, T. J. Jaworski, K. K. Midha, G. McKay, J. W. Hubbard, E. D. Korchinski
  
  Pages 263-286
4. Purification and characterization of rat hepatic acetyltransferase
  
  C. M. King, S. J. Land
  
  Pages 287-292

Keywords

Editors and Affiliations

Ludwig-Maximilians-Universität München, Munich, Germany

P. Hlavica
Chelsea Department of Pharmacy, King’s College, University of London, UK

L. A. Damani

Bibliographic Information

Book Title: N-Oxidation of Drugs
Book Subtitle: Biochemistry, pharmacology, toxicology
Editors: P. Hlavica, L. A. Damani
DOI: https://doi.org/10.1007/978-94-011-3112-4
Publisher: Springer Dordrecht
eBook Packages: Springer Book Archive
Hardcover ISBN: 978-0-412-36030-5Published: 30 June 1991
Softcover ISBN: 978-94-010-5378-5Published: 24 September 2012
eBook ISBN: 978-94-011-3112-4Published: 06 December 2012
Edition Number: 1
Number of Pages: XX, 487
Topics: Pharmacology/Toxicology, Biochemistry, general

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N-Oxidation of Drugs

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Table of contents (26 chapters)

Front Matter

Analysis of N-Oxidized Products

Front Matter

Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products

The Application of ¹⁵N-NMR in the Analysis of N-Oxygenated amidines and guanidines

Radioimmunoassay and other methods for trace analysis of N-oxide compounds

Enzymology of N-Oxidation

Front Matter

Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenases

On the genetic polymorphism of the flavin-containing mono-oxygenase

Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenase

Human pharmacogenetics of nitrogen oxidations

Microbial N-hydroxylases

Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylamines, and N,N-dimethylanilines by cytochrome P-450 enzymes

The role of cytochrome P-450 in the biological nuclear N-oxidation of aminoaza-heterocyclic drugs and related compounds

New aspects of the microsomal N-hydroxylation of benzamidines

Studies on the N-oxidation of phentermine: evidence for an indirect pathway of N-oxidation mediated by cytochrome P-450

Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase products

Reductions and Conjugations of N-Oxygenated Compounds

Front Matter

Reduction and conjugation reactions of N-oxides

In vivo metabolism of N-oxides

Purification and characterization of rat hepatic acetyltransferase

Keywords

Editors and Affiliations

Ludwig-Maximilians-Universität München, Munich, Germany

Chelsea Department of Pharmacy, King’s College, University of London, UK

Bibliographic Information

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Buy it now

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Editors:

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Table of contents (26 chapters)

Front Matter

Analysis of N-Oxidized Products

Front Matter

Enzymology of N-Oxidation

Front Matter

Reductions and Conjugations of N-Oxygenated Compounds

Front Matter

Keywords

Editors and Affiliations

Ludwig-Maximilians-Universität München, Munich, Germany

Chelsea Department of Pharmacy, King’s College, University of London, UK

Bibliographic Information

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